Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an In Vitro Pharmacokinetic/Pharmacodynamic Model

This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resista...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2020-12, Vol.65 (1)
Hauptverfasser: Kebriaei, Razieh, Lev, Katherine L, Stamper, Kyle C, Lehman, Susan M, Morales, Sandra, Rybak, Michael J
Format: Artikel
Sprache:eng
Schlagworte:
Experimental Therapeutics
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Zusammenfassung:This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant (MRSA) infections.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01863-20