RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion

Cdc42-GTP is required for apical domain formation in epithelial cells, where it recruits and activates the Par-6-aPKC polarity complex, but how the activity of Cdc42 itself is restricted apically is unclear. We used sequence analysis and 3D structural modeling to determine which Drosophila GTPase-ac...

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Veröffentlicht in:The Journal of cell biology 2021-04, Vol.220 (4), p.1
Hauptverfasser: Fic, Weronika, Bastock, Rebecca, Raimondi, Francesco, Los, Erinn, Inoue, Yoshiko, Gallop, Jennifer L, Russell, Robert B, St Johnston, Daniel
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Sprache:eng
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