Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial

Targeted preventive therapy for individuals at highest risk of incident tuberculosis might impact the epidemic by interrupting transmission. We tested performance of a transcriptomic signature of tuberculosis (RISK11) and efficacy of signature-guided preventive therapy in parallel, using a hybrid th...

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Veröffentlicht in:	The Lancet infectious diseases 2021-03, Vol.21 (3), p.354-365
Hauptverfasser:	Scriba, Thomas J, Fiore-Gartland, Andrew, Borate, Bhavesh, Mendelsohn, Simon C, Hadley, Katie, Hikuam, Chris, Kaskar, Masooda, Bilek, Nicole, Self, Steven, Sumner, Tom, White, Richard G, Jaxa, Lungisa, Raphela, Rodney, Brumskine, William, Hiemstra, Andriëtte, Malherbe, Stephanus T, Naidoo, Kogieleum, Churchyard, Gavin, Hatherill, Mark, Baepanye, Kesenogile, Baepanye, Tshepiso, Clarke, Ken, Collignon, Marelize, Dlamini, Audrey, Eyre, Candice, Fikizolo, Moogo, Goliath, Thelma, Malefo-Grootboom, Shirley, Janse van Rensburg, Elba, Janse van Rensburg, Bonita, Kock, Adrianne, Lakhi, Aneessa, Langa, Nondumiso, Mabasa, Immaculate, Mabe, Dorah, Mabuza, Nkosinathi, Majola, Molly, Makhubalo, Blossom, Malay, Vernon, Market, Juanita, Mbipa, Nontsikelelo, Mmotsa, Tsiamo, Modipa, Sylvester, Moswegu, Palesa, Nel, Maryna, Ntamo, Bantubonke, Ntoahae, Lawerence, Ntshauba, Tedrius, Seabela, Letlhogonolo, Selepe, Pearl, Senne, Melissa, Serake, MG, Tshikovhi, Vincent, Tswaile, Lebogang, van Aswegen, Amanda, Mbata, Lungile, Takavamanya, Constance, Taljaard, Marthinette, Sayed, Sharfuddin, Nielson, Tanya, Ni Sein, Ni, Zulu, Mbali Ignatia, Maphanga, Nonhle Bridgette, Hlathi, Senzo Ralph, Gumede, Goodness Khanyisile, Jali, Zandile Patrica, Cwele, Thobelani, Dlamini, Celaphiwe, Nzimande, Sphelele Simo, Maharaj, Bhavna, Moosa, Atika, Corris, Cara-Mia, Luabeya, Angelique Kany Kany, Shenje, Justin, Rossouw, Susan, Braaf, Samentra, Carstens, Alida, Jansen, Ruwiyda, Mabwe, Simbarashe, Mulenga, Humphrey, Veldsman, Ashley, Makhete, Lebohgang, Steyn, Marcia, Buhlungu, Sivuyile, Erasmus, Margareth, Plaatjie, Patiswa, Veldtsman, Helen, Petersen, Christel, Moses, Miriam, Magawu, Nomsitho, Mactavie, Lauren, Filander, Elizabeth, Nqakala, Nambitha, Khoury, Justine, Kriel, Belinda, Tonsing, Susanne, Ahlers, Petri, Flinn, Marika, Chung, Eva, Sato, Alicia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adverse events Analysis Antitubercular Agents - therapeutic use Biomarkers Biomarkers - metabolism Cancer Charities Clinical trials Diagnostic systems Discrimination Disease prevention Drug Administration Schedule Epidemiology Female Gene expression Health services HIV HIV Seronegativity Human immunodeficiency virus Humans Immunology Incidence Infections Infectious diseases Isoniazid Isoniazid - therapeutic use Male Medical research Medicine, Preventive Mycobacterium tuberculosis - genetics Oncology, Experimental Overdose Polymerase chain reaction Preventive health services Reverse Transcriptase Polymerase Chain Reaction Rifampin - analogs & derivatives Rifampin - therapeutic use Rifapentine RNA, Bacterial - metabolism Seizures South Africa - epidemiology Surveillance Therapy Treatment Outcome Tuberculosis Tuberculosis - epidemiology Tuberculosis - genetics Tuberculosis - metabolism Tuberculosis - prevention & control Vaccines Young Adult
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Zusammenfassung:	Targeted preventive therapy for individuals at highest risk of incident tuberculosis might impact the epidemic by interrupting transmission. We tested performance of a transcriptomic signature of tuberculosis (RISK11) and efficacy of signature-guided preventive therapy in parallel, using a hybrid three-group study design. Adult volunteers aged 18–59 years were recruited at five geographically distinct communities in South Africa. Whole blood was sampled for RISK11 by quantitative RT-PCR assay from eligible volunteers without HIV, recent previous tuberculosis (ie,
ISSN:	1473-3099 1474-4457
DOI:	10.1016/S1473-3099(20)30914-2