Chimeric hepatitis E virus-like particle as a carrier for oral-delivery
Highlights ► Sequence insertion at antigenic domain of HEV-VLP does not interfere with icosahedral assembly. ► Sequence insertion induces conformational changes at HEV antigenic domain leading to deterioration in antibody-binding. ► Sequence insertion introduces a trypsin cleavage site in the recomb...
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| Veröffentlicht in: | Vaccine 2013-01, Vol.31 (2), p.417-424 |
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| creator | Jariyapong, Pitchanee Xing, Li van Houten, Nienke E Li, Tian-Cheng Weerachatyanukul, Wattana Hsieh, Benjamin Moscoso, Carlos G Chen, Chun-Chieh Niikura, Masahiro Cheng, R. Holland |
| description | Highlights ► Sequence insertion at antigenic domain of HEV-VLP does not interfere with icosahedral assembly. ► Sequence insertion induces conformational changes at HEV antigenic domain leading to deterioration in antibody-binding. ► Sequence insertion introduces a trypsin cleavage site in the recombinant HEV capsid protein. ► The chimeric VLP remains intact after trypsin cleavage. |
| doi_str_mv | 10.1016/j.vaccine.2012.10.073 |
| format | Article |
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Holland</creatorcontrib><description>Highlights ► Sequence insertion at antigenic domain of HEV-VLP does not interfere with icosahedral assembly. ► Sequence insertion induces conformational changes at HEV antigenic domain leading to deterioration in antibody-binding. ► Sequence insertion introduces a trypsin cleavage site in the recombinant HEV capsid protein. ► The chimeric VLP remains intact after trypsin cleavage.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2012.10.073</identifier><identifier>PMID: 23107594</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Administration, Oral ; Allergy and Immunology ; Amino Acid Sequence ; Amino acids ; Antibodies ; Antigens, Viral - genetics ; Antigens, Viral - immunology ; Applied microbiology ; Binding Sites ; Biological and medical sciences ; capsid ; Capsid protein ; Capsid Proteins - genetics ; Capsid Proteins - immunology ; Capsids ; chimerism ; coat proteins ; Digestive tract ; Fourier transforms ; Fundamental and applied biological sciences. Psychology ; Glycoprotein gp120 ; Hepatitis ; Hepatitis Antibodies - immunology ; hepatitis E ; Hepatitis E virus ; Hepatitis E virus - genetics ; Hepatitis E virus - immunology ; HIV Envelope Protein gp120 - genetics ; HIV Envelope Protein gp120 - immunology ; HIV-1 epitope ; Human immunodeficiency virus 1 ; humans ; humoral immunity ; Immunity (humoral) ; Insertion ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Mutation ; Peptides ; Protein structure ; Proteins ; Quaternary structure ; Recombinant capsid protein ; Recombinant Fusion Proteins - genetics ; Recombinant Fusion Proteins - immunology ; Trypsin ; Trypsin proteolysis ; vaccines ; Vaccines - administration & dosage ; Vaccines - genetics ; Vaccines - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Virology ; Virus like particle ; Virus-like particles</subject><ispartof>Vaccine, 2013-01, Vol.31 (2), p.417-424</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 2, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c637t-baab0075c666e766f54ce677df6e7ea0bb381ff7a845cece12e2320f6faff74a3</citedby><cites>FETCH-LOGICAL-c637t-baab0075c666e766f54ce677df6e7ea0bb381ff7a845cece12e2320f6faff74a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1552014143?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27090962$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23107594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jariyapong, Pitchanee</creatorcontrib><creatorcontrib>Xing, Li</creatorcontrib><creatorcontrib>van Houten, Nienke E</creatorcontrib><creatorcontrib>Li, Tian-Cheng</creatorcontrib><creatorcontrib>Weerachatyanukul, Wattana</creatorcontrib><creatorcontrib>Hsieh, Benjamin</creatorcontrib><creatorcontrib>Moscoso, Carlos G</creatorcontrib><creatorcontrib>Chen, Chun-Chieh</creatorcontrib><creatorcontrib>Niikura, Masahiro</creatorcontrib><creatorcontrib>Cheng, R. Holland</creatorcontrib><title>Chimeric hepatitis E virus-like particle as a carrier for oral-delivery</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights ► Sequence insertion at antigenic domain of HEV-VLP does not interfere with icosahedral assembly. ► Sequence insertion induces conformational changes at HEV antigenic domain leading to deterioration in antibody-binding. ► Sequence insertion introduces a trypsin cleavage site in the recombinant HEV capsid protein. ► The chimeric VLP remains intact after trypsin cleavage.</description><subject>Administration, Oral</subject><subject>Allergy and Immunology</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Antibodies</subject><subject>Antigens, Viral - genetics</subject><subject>Antigens, Viral - immunology</subject><subject>Applied microbiology</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>capsid</subject><subject>Capsid protein</subject><subject>Capsid Proteins - genetics</subject><subject>Capsid Proteins - immunology</subject><subject>Capsids</subject><subject>chimerism</subject><subject>coat proteins</subject><subject>Digestive tract</subject><subject>Fourier transforms</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycoprotein gp120</subject><subject>Hepatitis</subject><subject>Hepatitis Antibodies - immunology</subject><subject>hepatitis E</subject><subject>Hepatitis E virus</subject><subject>Hepatitis E virus - genetics</subject><subject>Hepatitis E virus - immunology</subject><subject>HIV Envelope Protein gp120 - genetics</subject><subject>HIV Envelope Protein gp120 - immunology</subject><subject>HIV-1 epitope</subject><subject>Human immunodeficiency virus 1</subject><subject>humans</subject><subject>humoral immunity</subject><subject>Immunity (humoral)</subject><subject>Insertion</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Peptides</subject><subject>Protein structure</subject><subject>Proteins</subject><subject>Quaternary structure</subject><subject>Recombinant capsid protein</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Recombinant Fusion Proteins - immunology</subject><subject>Trypsin</subject><subject>Trypsin proteolysis</subject><subject>vaccines</subject><subject>Vaccines - administration & dosage</subject><subject>Vaccines - genetics</subject><subject>Vaccines - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Virology</subject><subject>Virus like particle</subject><subject>Virus-like particles</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl9v0zAUxS0EYl3hIwCR0CReUvwnsZuXIVSNgTSJhzGJN-vWuV7dpUlnJ5X67blRywZ7AfnB8vXP18fnmLE3gs8EF_rjerYD50KLM8mFpNqMG_WMTcTcqFyWYv6cTbjURV4I_vOEnaa05pyXSlQv2YlUgpuyKibscrEKG4zBZSvcQh_6kLKLbBfikPIm3GG2hdgH12AGKYPMQYwBY-a7mHURmrzGJuww7l-xFx6ahK-P85TdfLn4sfiaX32__Lb4fJU7rUyfLwGWnK52Wms0WvuycKiNqT0tEfhyqebCewPzonToUEiUSnKvPVC1ADVl54e-22G5wdph25MMu41hA3FvOwj27502rOxtt7OmIpvImyn7cGwQu_sBU283ITlsGmixG5IV0qhCCynU_6A0KiUkoe-foOtuiC05YUVZUkKFKMaG5YFysUspon_QLbgdU7Vre0zVjqmOZUqVzr3989EPp37HSMDZEYDkoPERWhfSI2d4xSs9ynx34Dx0Fm4jMTfXdFPJuTBkOSfi04FACnFHUdvkArYO6xDR9bbuwj_Fnj_p4JrQBpJ1h3tMj77YJC231-MnHf-oGHUoJdUvDCDg6A</recordid><startdate>20130102</startdate><enddate>20130102</enddate><creator>Jariyapong, Pitchanee</creator><creator>Xing, Li</creator><creator>van Houten, Nienke E</creator><creator>Li, Tian-Cheng</creator><creator>Weerachatyanukul, Wattana</creator><creator>Hsieh, Benjamin</creator><creator>Moscoso, Carlos G</creator><creator>Chen, Chun-Chieh</creator><creator>Niikura, Masahiro</creator><creator>Cheng, R. 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Psychology</topic><topic>Glycoprotein gp120</topic><topic>Hepatitis</topic><topic>Hepatitis Antibodies - immunology</topic><topic>hepatitis E</topic><topic>Hepatitis E virus</topic><topic>Hepatitis E virus - genetics</topic><topic>Hepatitis E virus - immunology</topic><topic>HIV Envelope Protein gp120 - genetics</topic><topic>HIV Envelope Protein gp120 - immunology</topic><topic>HIV-1 epitope</topic><topic>Human immunodeficiency virus 1</topic><topic>humans</topic><topic>humoral immunity</topic><topic>Immunity (humoral)</topic><topic>Insertion</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Peptides</topic><topic>Protein structure</topic><topic>Proteins</topic><topic>Quaternary structure</topic><topic>Recombinant capsid protein</topic><topic>Recombinant Fusion Proteins - genetics</topic><topic>Recombinant Fusion Proteins - immunology</topic><topic>Trypsin</topic><topic>Trypsin proteolysis</topic><topic>vaccines</topic><topic>Vaccines - administration & dosage</topic><topic>Vaccines - genetics</topic><topic>Vaccines - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Virology</topic><topic>Virus like particle</topic><topic>Virus-like particles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jariyapong, Pitchanee</creatorcontrib><creatorcontrib>Xing, Li</creatorcontrib><creatorcontrib>van Houten, Nienke E</creatorcontrib><creatorcontrib>Li, Tian-Cheng</creatorcontrib><creatorcontrib>Weerachatyanukul, Wattana</creatorcontrib><creatorcontrib>Hsieh, Benjamin</creatorcontrib><creatorcontrib>Moscoso, Carlos G</creatorcontrib><creatorcontrib>Chen, Chun-Chieh</creatorcontrib><creatorcontrib>Niikura, Masahiro</creatorcontrib><creatorcontrib>Cheng, R. 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| fulltext | fulltext |
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| ispartof | Vaccine, 2013-01, Vol.31 (2), p.417-424 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7901287 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Administration, Oral Allergy and Immunology Amino Acid Sequence Amino acids Antibodies Antigens, Viral - genetics Antigens, Viral - immunology Applied microbiology Binding Sites Biological and medical sciences capsid Capsid protein Capsid Proteins - genetics Capsid Proteins - immunology Capsids chimerism coat proteins Digestive tract Fourier transforms Fundamental and applied biological sciences. Psychology Glycoprotein gp120 Hepatitis Hepatitis Antibodies - immunology hepatitis E Hepatitis E virus Hepatitis E virus - genetics Hepatitis E virus - immunology HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV-1 epitope Human immunodeficiency virus 1 humans humoral immunity Immunity (humoral) Insertion Microbiology Miscellaneous Molecular Sequence Data Mutation Peptides Protein structure Proteins Quaternary structure Recombinant capsid protein Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Trypsin Trypsin proteolysis vaccines Vaccines - administration & dosage Vaccines - genetics Vaccines - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology Virus like particle Virus-like particles |
| title | Chimeric hepatitis E virus-like particle as a carrier for oral-delivery |
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