Vaccine Efficacy of ALVAC-HIV and Bivalent Subtype C gp120–MF59 in Adults

In this trial, investigators evaluated the efficacy of the ALVAC–gp120 HIV vaccine in 5404 healthy adults in South Africa. At 24 months, there was no significant difference in the incidence of HIV-1 infection between the vaccine group and the placebo group.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-03, Vol.384 (12), p.1089-1100
Hauptverfasser:	Gray, Glenda E, Bekker, Linda-Gail, Laher, Fatima, Malahleha, Mookho, Allen, Mary, Moodie, Zoe, Grunenberg, Nicole, Huang, Yunda, Grove, Doug, Prigmore, Brittany, Kee, Jia J, Benkeser, David, Hural, John, Innes, Craig, Lazarus, Erica, Meintjes, Graeme, Naicker, Nivashnee, Kalonji, Dishiki, Nchabeleng, Maphoshane, Sebe, Modulakgotla, Singh, Nishanta, Kotze, Philip, Kassim, Sheetal, Dubula, Thozama, Naicker, Vimla, Brumskine, William, Ncayiya, Cleon N, Ward, Amy M, Garrett, Nigel, Kistnasami, Girisha, Gaffoor, Zakir, Selepe, Pearl, Makhoba, Philisiwe B, Mathebula, Matsontso P, Mda, Pamela, Adonis, Tania, Mapetla, Katlego S, Modibedi, Bontle, Philip, Tricia, Kobane, Gladys, Bentley, Carter, Ramirez, Shelly, Takuva, Simbarashe, Jones, Megan, Sikhosana, Mpho, Atujuna, Millicent, Andrasik, Michele, Hejazi, Nima S, Puren, Adrian, Wiesner, Lubbe, Phogat, Sanjay, Diaz Granados, Carlos, Koutsoukos, Marguerite, Van Der Meeren, Olivier, Barnett, Susan W, Kanesa-Thasan, Niranjan, Kublin, James G, McElrath, M. Juliana, Gilbert, Peter B, Janes, Holly, Corey, Lawrence
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adjuvants, Immunologic Adolescent Adult Adverse events AIDS AIDS Vaccines - immunology Breastfeeding & lactation Canarypox virus Double-Blind Method Enrollments Female Genetic Vectors Glycoprotein gp120 Glycoproteins HIV HIV Infections - prevention & control HIV-1 - genetics Human immunodeficiency virus Humans Immunization Immunization, Secondary Immunogenicity Immunogenicity, Vaccine Infections Male Placebos Polysorbates Population South Africa Squalene Statistical analysis Treatment Failure Vaccine efficacy Vaccines Womens health Young Adult
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Beschreibung
Zusammenfassung:	In this trial, investigators evaluated the efficacy of the ALVAC–gp120 HIV vaccine in 5404 healthy adults in South Africa. At 24 months, there was no significant difference in the incidence of HIV-1 infection between the vaccine group and the placebo group.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2031499