Ebola Virus Transmission Initiated by Systemic Ebola Virus Disease Relapse

Ebola Virus Transmission Initiated by Systemic Ebola Virus Disease Relapse

During the 2018-2020 Nord Kivu Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo, an individual who had received the Merck rVSV-ZEBOV vaccine was diagnosed with EVD. His treatment included an Ebola virus-specific monoclonal antibody (mAb114), and he recovered within 14 days...

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Veröffentlicht in:The New England journal of medicine 2021-04, Vol.384 (13), p.1240-1247
Hauptverfasser: Mbala-Kingebeni, Placide, Pratt, Catherine, Ruffin, Mbusa Mutafali, Pauthner, Matthias G., Bile, Faustin, Nkuba Ndaye, Antoine, Black, Allison, Kinganda Lusamaki, Eddy, Faye, Martin, Aziza, Amuri, Diagne, Moussa M, Mukadi, Daniel, White, Bailey, Hadfield, James, Gangavarapu, Karthik, Bisento, Nella, Kazadi, Donatien, Nsunda, Bibiche, Akonga, Marceline, Tshiani, Olivier, Misasi, John, Ploquin, Aurelie, Epaso, Victor, Sana Paka, Emilia, N’kasar, Yannick Tutu Tshia, Mambu, Fabrice, Edidi, Francois, Matondo, Meris, Bula Bula, Junior, Diallo, Boubacar, Keita, Mory, Belizaire, Marie Roseline Darnycka, Fall, Ibrahima Soce, Yam, Abdoulaye, Sabue, Mulangu, Rimion, Anne W., Salfati, Elias, Torkamani, Ali, Suchard, Marc A., Crozier, Ian, Hensley, Lisa, Rambaut, Andrew, Faye, Ousmane, Sall, Amadou, Sullivan, Nancy J., Bedford, Trevor, Andersen, Kristian G., Wiley, Michael R., Ahuka-Mundeke, Steve, Muyembe Tamfum, Jean-Jacques
Format: Artikel
Sprache:eng
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Zusammenfassung:During the 2018-2020 Nord Kivu Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo, an individual who had received the Merck rVSV-ZEBOV vaccine was diagnosed with EVD. His treatment included an Ebola virus-specific monoclonal antibody (mAb114), and he recovered within 14 days but re-presented six months later with severe EVD-like illness and Ebola virus viremia and died. We initiated an epidemiological and genomic investigation that showed the patient had a relapse of acute EVD, which led to a transmission chain that resulted in 91 cases spanning six health zones over four-months.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2024670