Delivery-based criteria for empiric antibiotic administration among preterm infants
Objective Determine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. Study design Single site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or...
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| Veröffentlicht in: | Journal of perinatology 2021-02, Vol.41 (2), p.255-262 |
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| creator | Garber, Samuel J. Dhudasia, Miren B. Flannery, Dustin D. Passarella, Molly R. Puopolo, Karen M. Mukhopadhyay, Sagori |
| description | Objective
Determine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants.
Study design
Single site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or membrane rupture were categorized as low-risk for early-onset infection and managed without empiric antibiotics. We determined effect of this guideline by pre-post, and interrupted time-series analyses.
Results
After 04/2017, antibiotic initiation ≤3 days decreased among low-risk VLBW (62% vs. 13%,
p
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| doi_str_mv | 10.1038/s41372-020-00784-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7881045</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A655716290</galeid><sourcerecordid>A655716290</sourcerecordid><originalsourceid>FETCH-LOGICAL-c572t-e50fbdd51f0ebd804e0113e1e17d6b304e84f6aa5d8e80981fdc5cbde9011d0f3</originalsourceid><addsrcrecordid>eNp9ks1u1DAUhSMEokPhBVigSEgVmxQ7tmNng1SVX6kSC2BtOfb1jKvEHuxMpXl7bpjSdhBCWSTx_c6JfXKq6iUl55Qw9bZwymTbkJY0hEjFm_2jakW57BohOHtcrYjkrFGMdyfVs1KuCVmG8ml1wlrZt13br6pv72EMN5D3zWAKuNrmMEMOpvYp1zBtQw62NnEOQ0jz8uimEEOZs5lDirWZUlzX2wwomuoQPaLlefXEm7HAi9v7afXj44fvl5-bq6-fvlxeXDVWyHZuQBA_OCeoJzA4RTgQShlQoNJ1A8N3xX1njHAKFOkV9c4KOzjokXPEs9Pq3cF3uxsmcBYibmvU2xwmk_c6maCPJzFs9DrdaKkUJVygwZtbg5x-7qDMegrFwjiaCGlXdMsZ5wqzZIi-_gu9Trsc8XhIqb4ngnftPbU2I2iMI-F37WKqLzohJMXMCVLn_6DwcjAFmyL4gOtHgrMHgg2Ycd6UNO6WX1COwfYA2pxKyeDvwqBEL53Rh85o7Iz-3Rm9R9GrhzHeSf6UBAF2AAqO4hry_dn_Y_sLuD_NZQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2489905462</pqid></control><display><type>article</type><title>Delivery-based criteria for empiric antibiotic administration among preterm infants</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Garber, Samuel J. ; Dhudasia, Miren B. ; Flannery, Dustin D. ; Passarella, Molly R. ; Puopolo, Karen M. ; Mukhopadhyay, Sagori</creator><creatorcontrib>Garber, Samuel J. ; Dhudasia, Miren B. ; Flannery, Dustin D. ; Passarella, Molly R. ; Puopolo, Karen M. ; Mukhopadhyay, Sagori</creatorcontrib><description>Objective
Determine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants.
Study design
Single site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or membrane rupture were categorized as low-risk for early-onset infection and managed without empiric antibiotics. We determined effect of this guideline by pre-post, and interrupted time-series analyses.
Results
After 04/2017, antibiotic initiation ≤3 days decreased among low-risk VLBW (62% vs. 13%,
p
< 0.001) and low-risk ELBW (88% vs. 21%,
p
< 0.001) infants. In time series analysis, guideline was associated with decreased initiation among low-risk ELBW infants. In contrast, low-risk VLBW infants demonstrated decreased antibiotic initiation throughout study period. Incidence of confirmed infection, death, or transfer ≤7 days age was unchanged.
Conclusion
Delivery criteria may be used to optimize early antibiotic initiation among preterm infants without short-term increase in adverse outcomes.</description><identifier>ISSN: 0743-8346</identifier><identifier>ISSN: 1476-5543</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-020-00784-y</identifier><identifier>PMID: 32792629</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/699/255 ; 692/700/1720 ; Age ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Birth weight ; Cesarean Section ; Childbirth ; Cohort Studies ; Criteria ; Drug therapy ; Female ; Health aspects ; Health risks ; Humans ; Infant ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Infants ; Infants (Premature) ; Infections ; Low birth weight ; Medicine ; Medicine & Public Health ; Neonates ; Newborn babies ; Pediatric research ; Pediatric Surgery ; Pediatrics ; Pregnancy ; Premature babies ; Premature birth ; Prognosis ; Risk ; Risk management ; Time series ; Weight</subject><ispartof>Journal of perinatology, 2021-02, Vol.41 (2), p.255-262</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-e50fbdd51f0ebd804e0113e1e17d6b304e84f6aa5d8e80981fdc5cbde9011d0f3</citedby><cites>FETCH-LOGICAL-c572t-e50fbdd51f0ebd804e0113e1e17d6b304e84f6aa5d8e80981fdc5cbde9011d0f3</cites><orcidid>0000-0002-2448-1019 ; 0000-0002-5851-8414 ; 0000-0003-2883-4683</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-020-00784-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-020-00784-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32792629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garber, Samuel J.</creatorcontrib><creatorcontrib>Dhudasia, Miren B.</creatorcontrib><creatorcontrib>Flannery, Dustin D.</creatorcontrib><creatorcontrib>Passarella, Molly R.</creatorcontrib><creatorcontrib>Puopolo, Karen M.</creatorcontrib><creatorcontrib>Mukhopadhyay, Sagori</creatorcontrib><title>Delivery-based criteria for empiric antibiotic administration among preterm infants</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
Determine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants.
Study design
Single site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or membrane rupture were categorized as low-risk for early-onset infection and managed without empiric antibiotics. We determined effect of this guideline by pre-post, and interrupted time-series analyses.
Results
After 04/2017, antibiotic initiation ≤3 days decreased among low-risk VLBW (62% vs. 13%,
p
< 0.001) and low-risk ELBW (88% vs. 21%,
p
< 0.001) infants. In time series analysis, guideline was associated with decreased initiation among low-risk ELBW infants. In contrast, low-risk VLBW infants demonstrated decreased antibiotic initiation throughout study period. Incidence of confirmed infection, death, or transfer ≤7 days age was unchanged.
Conclusion
Delivery criteria may be used to optimize early antibiotic initiation among preterm infants without short-term increase in adverse outcomes.</description><subject>692/699/255</subject><subject>692/700/1720</subject><subject>Age</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Birth weight</subject><subject>Cesarean Section</subject><subject>Childbirth</subject><subject>Cohort Studies</subject><subject>Criteria</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Extremely Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Very Low Birth Weight</subject><subject>Infants</subject><subject>Infants (Premature)</subject><subject>Infections</subject><subject>Low birth weight</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Pediatric research</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Premature babies</subject><subject>Premature birth</subject><subject>Prognosis</subject><subject>Risk</subject><subject>Risk management</subject><subject>Time series</subject><subject>Weight</subject><issn>0743-8346</issn><issn>1476-5543</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks1u1DAUhSMEokPhBVigSEgVmxQ7tmNng1SVX6kSC2BtOfb1jKvEHuxMpXl7bpjSdhBCWSTx_c6JfXKq6iUl55Qw9bZwymTbkJY0hEjFm_2jakW57BohOHtcrYjkrFGMdyfVs1KuCVmG8ml1wlrZt13br6pv72EMN5D3zWAKuNrmMEMOpvYp1zBtQw62NnEOQ0jz8uimEEOZs5lDirWZUlzX2wwomuoQPaLlefXEm7HAi9v7afXj44fvl5-bq6-fvlxeXDVWyHZuQBA_OCeoJzA4RTgQShlQoNJ1A8N3xX1njHAKFOkV9c4KOzjokXPEs9Pq3cF3uxsmcBYibmvU2xwmk_c6maCPJzFs9DrdaKkUJVygwZtbg5x-7qDMegrFwjiaCGlXdMsZ5wqzZIi-_gu9Trsc8XhIqb4ngnftPbU2I2iMI-F37WKqLzohJMXMCVLn_6DwcjAFmyL4gOtHgrMHgg2Ycd6UNO6WX1COwfYA2pxKyeDvwqBEL53Rh85o7Iz-3Rm9R9GrhzHeSf6UBAF2AAqO4hry_dn_Y_sLuD_NZQ</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Garber, Samuel J.</creator><creator>Dhudasia, Miren B.</creator><creator>Flannery, Dustin D.</creator><creator>Passarella, Molly R.</creator><creator>Puopolo, Karen M.</creator><creator>Mukhopadhyay, Sagori</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2448-1019</orcidid><orcidid>https://orcid.org/0000-0002-5851-8414</orcidid><orcidid>https://orcid.org/0000-0003-2883-4683</orcidid></search><sort><creationdate>20210201</creationdate><title>Delivery-based criteria for empiric antibiotic administration among preterm infants</title><author>Garber, Samuel J. ; Dhudasia, Miren B. ; Flannery, Dustin D. ; Passarella, Molly R. ; Puopolo, Karen M. ; Mukhopadhyay, Sagori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-e50fbdd51f0ebd804e0113e1e17d6b304e84f6aa5d8e80981fdc5cbde9011d0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/699/255</topic><topic>692/700/1720</topic><topic>Age</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Birth weight</topic><topic>Cesarean Section</topic><topic>Childbirth</topic><topic>Cohort Studies</topic><topic>Criteria</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Extremely Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Very Low Birth Weight</topic><topic>Infants</topic><topic>Infants (Premature)</topic><topic>Infections</topic><topic>Low birth weight</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Pediatric research</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Premature babies</topic><topic>Premature birth</topic><topic>Prognosis</topic><topic>Risk</topic><topic>Risk management</topic><topic>Time series</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garber, Samuel J.</creatorcontrib><creatorcontrib>Dhudasia, Miren B.</creatorcontrib><creatorcontrib>Flannery, Dustin D.</creatorcontrib><creatorcontrib>Passarella, Molly R.</creatorcontrib><creatorcontrib>Puopolo, Karen M.</creatorcontrib><creatorcontrib>Mukhopadhyay, Sagori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garber, Samuel J.</au><au>Dhudasia, Miren B.</au><au>Flannery, Dustin D.</au><au>Passarella, Molly R.</au><au>Puopolo, Karen M.</au><au>Mukhopadhyay, Sagori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delivery-based criteria for empiric antibiotic administration among preterm infants</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>41</volume><issue>2</issue><spage>255</spage><epage>262</epage><pages>255-262</pages><issn>0743-8346</issn><issn>1476-5543</issn><eissn>1476-5543</eissn><abstract>Objective
Determine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants.
Study design
Single site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or membrane rupture were categorized as low-risk for early-onset infection and managed without empiric antibiotics. We determined effect of this guideline by pre-post, and interrupted time-series analyses.
Results
After 04/2017, antibiotic initiation ≤3 days decreased among low-risk VLBW (62% vs. 13%,
p
< 0.001) and low-risk ELBW (88% vs. 21%,
p
< 0.001) infants. In time series analysis, guideline was associated with decreased initiation among low-risk ELBW infants. In contrast, low-risk VLBW infants demonstrated decreased antibiotic initiation throughout study period. Incidence of confirmed infection, death, or transfer ≤7 days age was unchanged.
Conclusion
Delivery criteria may be used to optimize early antibiotic initiation among preterm infants without short-term increase in adverse outcomes.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>32792629</pmid><doi>10.1038/s41372-020-00784-y</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2448-1019</orcidid><orcidid>https://orcid.org/0000-0002-5851-8414</orcidid><orcidid>https://orcid.org/0000-0003-2883-4683</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2021-02, Vol.41 (2), p.255-262 |
| issn | 0743-8346 1476-5543 1476-5543 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7881045 |
| source | MEDLINE; SpringerLink Journals |
| subjects | 692/699/255 692/700/1720 Age Anti-Bacterial Agents - therapeutic use Antibiotics Birth weight Cesarean Section Childbirth Cohort Studies Criteria Drug therapy Female Health aspects Health risks Humans Infant Infant, Extremely Low Birth Weight Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Infants Infants (Premature) Infections Low birth weight Medicine Medicine & Public Health Neonates Newborn babies Pediatric research Pediatric Surgery Pediatrics Pregnancy Premature babies Premature birth Prognosis Risk Risk management Time series Weight |
| title | Delivery-based criteria for empiric antibiotic administration among preterm infants |
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