Delivery-based criteria for empiric antibiotic administration among preterm infants

Delivery-based criteria for empiric antibiotic administration among preterm infants

Objective Determine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. Study design Single site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or...

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Veröffentlicht in:Journal of perinatology 2021-02, Vol.41 (2), p.255-262
Hauptverfasser: Garber, Samuel J., Dhudasia, Miren B., Flannery, Dustin D., Passarella, Molly R., Puopolo, Karen M., Mukhopadhyay, Sagori
Format: Artikel
Sprache:eng
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692/699/255
692/700/1720
Age
Anti-Bacterial Agents - therapeutic use
Antibiotics
Birth weight
Cesarean Section
Childbirth
Cohort Studies
Criteria
Drug therapy
Female
Health aspects
Health risks
Humans
Infant
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Infants
Infants (Premature)
Infections
Low birth weight
Medicine
Medicine & Public Health
Neonates
Newborn babies
Pediatric research
Pediatric Surgery
Pediatrics
Pregnancy
Premature babies
Premature birth
Prognosis
Risk
Risk management
Time series
Weight
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Beschreibung
Zusammenfassung:Objective Determine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. Study design Single site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or membrane rupture were categorized as low-risk for early-onset infection and managed without empiric antibiotics. We determined effect of this guideline by pre-post, and interrupted time-series analyses. Results After 04/2017, antibiotic initiation ≤3 days decreased among low-risk VLBW (62% vs. 13%, p  
ISSN:0743-8346
1476-5543
1476-5543
DOI:10.1038/s41372-020-00784-y