Effect of Prognostic Nutrition Index in Gastric or Gastro-oesophageal Junction Cancer Patients Undergoing Nivolumab Monotherapy

We hypothesised that the prognostic nutrition index (PNI) is useful for evaluating host immunity and response to immune checkpoint inhibitors. We investigated the effect of PNI on nivolumab monotherapy efficacy in advanced or recurrent gastric cancer (GC) or gastro-oesophageal junction cancer (GOC)...

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Veröffentlicht in:	In vivo (Athens) 2021-01, Vol.35 (1), p.563-569
Hauptverfasser:	Watanabe, Hayato, Yamada, Takanobu, Komori, Keisuke, Hara, Kentaro, Kano, Kazuki, Takahashi, Kosuke, Kumazu, Yuta, Fujikawa, Hirohito, Numata, Masakatsu, Aoyama, Toru, Tamagawa, Hiroshi, Inokuchi, Yasuhiro, Machida, Nozomu, Shiozawa, Manabu, Yukawa, Norio, Morinaga, Soichiro, Rino, Yasushi, Masuda, Munetaka, Ogata, Takashi, Oshima, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Neoplasm Recurrence, Local Nivolumab - adverse effects Nutrition Assessment Prognosis Retrospective Studies Stomach Neoplasms - drug therapy
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Zusammenfassung:	We hypothesised that the prognostic nutrition index (PNI) is useful for evaluating host immunity and response to immune checkpoint inhibitors. We investigated the effect of PNI on nivolumab monotherapy efficacy in advanced or recurrent gastric cancer (GC) or gastro-oesophageal junction cancer (GOC) patients. We retrospectively examined 110 patients, divided them into a high-PNI group and a low-PNI group, and compared treatment efficacy, adverse events (AEs), and survival between the groups. Median overall survival (OS) was significantly longer in the high-PNI group than in the low-PNI group (205 vs. 109 days; p
ISSN:	0258-851X 1791-7549 1791-7549
DOI:	10.21873/invivo.12292