Sex differences in response to allopurinol and benzbromarone in gout: a retrospective cohort study

Sex differences in response to allopurinol and benzbromarone in gout: a retrospective cohort study

Abstract Objective Owing to lower mean uric acid excretion in women compared with men, uricosuric agents might be preferred in women over xanthine oxidase (XO) inhibitors. We therefore investigated the differences in response to two urate-lowering therapies (ULTs) with different modes of action with...

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Veröffentlicht in:Rheumatology advances in practice 2021-01, Vol.5 (1), p.rkab002-rkab002
Hauptverfasser: Veenstra, Frouwke, Wanten, Sophie A C, Verhoef, Lise M, ter Stal, Minke, Kwok, Wing-Yee, van den Hoogen, Frank H J, Flendrie, Marcel, van Herwaarden, Noortje
Format: Artikel
Sprache:eng
Schlagworte:
Allopurinol
Analysis
Concise Report
Diagnosis
Gout
Medical research
Medicine, Experimental
Oxidases
Purines
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Zusammenfassung:Abstract Objective Owing to lower mean uric acid excretion in women compared with men, uricosuric agents might be preferred in women over xanthine oxidase (XO) inhibitors. We therefore investigated the differences in response to two urate-lowering therapies (ULTs) with different modes of action within and between sexes. Methods This retrospective cohort study included patients with a clinical diagnosis of gout who started allopurinol and/or benzbromarone. The successful response to ULT, defined as reaching a serum uric acid (sUA) target of
ISSN:2514-1775
2514-1775
DOI:10.1093/rap/rkab002