Fusion of the CRM1 nuclear export receptor to AF10 causes leukemia and transcriptional activation of HOXA genes

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Veröffentlicht in:	Leukemia 2021-03, Vol.35 (3), p.876-880
Hauptverfasser:	Aumann, Waitman K., Heath, Jessica L., Conway, Amanda E., Sze, Sei-Gyung Kim, Gupta, Veerain K., Kazi, Rafi R., Tope, Donald R., Wechsler, Daniel S., Lavau, Catherine P.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 38/109 38/70 38/77 631/67/1990/283/1897 631/67/1990/283/2125 631/67/395 64/60 82/1 82/80 Active Transport, Cell Nucleus Acute lymphocytic leukemia Amino acids Animals Apoptosis Cancer Cancer Research Care and treatment Cell Proliferation Cell receptors Cells, Cultured Critical Care Medicine Development and progression Exportin 1 Protein Gene Expression Regulation, Leukemic Genes Genetic aspects Health aspects Hematology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Intensive Internal Medicine Karyopherins - genetics Karyopherins - metabolism Letter Leukemia Leukemia, Experimental - etiology Leukemia, Experimental - metabolism Leukemia, Experimental - pathology Medicine Medicine & Public Health Mice Nuclear fusion Nuclear transport Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncology Pediatrics Proteins Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Transcription activation Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation
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ISSN:	0887-6924 1476-5551
DOI:	10.1038/s41375-020-0998-3