Clinical CAR-T Cell and Oncolytic Virotherapy for Cancer Treatment

Immunotherapy has recently garnered success with the induction of clinical responses in tumors, which are traditionally associated with poor outcomes. Chimeric antigen receptor T (CAR-T) cells and oncolytic viruses (OVs) have emerged as promising cancer immunotherapy agents. Herein, we provide an overview of the current clinical status of CAR-T cell and OV therapies. While preclinical studies have demonstrated curative potential, the benefit of CAR-T cells and OVs as single-agent treatments remains limited to a subset of patients. Combinations of different targeted therapies may be required to achieve efficient, durable responses against heterogeneous tumors, as well as the microenvironment. Using a combinatorial approach to take advantage of the unique features of CAR-T cells and OVs with other treatments can produce additive therapeutic effects. This review also discusses ongoing clinical evaluations of these combination strategies for improved outcomes in treatment of resistant malignancies. Chimeric antigen receptor modified T (CAR-T) cell and oncolytic viruses (OVs) are promising cancer immunotherapy platforms. Herein, Watanabe and colleagues review how these cancer gene therapy agents achieve clinical responses in tumors traditionally associated with poor outcomes and discusses emerging combinatorial strategies with radiotherapy/chemotherapy and other immunotherapies to improve clinical outcomes.