Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial

Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial

There is an ongoing debate on whether fructose plays a role in the development of nonalcoholic fatty liver disease. The aim of this study was to investigate the effects of fructose restriction on intrahepatic lipid (IHL) content in a double-blind randomized controlled trial using an isocaloric compa...

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Veröffentlicht in:The American journal of clinical nutrition 2021-02, Vol.113 (2), p.391-400
Hauptverfasser: Simons, Nynke, Veeraiah, Pandichelvam, Simons, Pomme IHG, Schaper, Nicolaas C, Kooi, M Eline, Schrauwen-Hinderling, Vera B, Feskens, Edith JM, van der Ploeg, EMC (Liesbeth), Van den Eynde, Mathias DG, Schalkwijk, Casper G, Stehouwer, Coen DA, Brouwers, Martijn CGJ
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Blood Glucose
Body weight
Clinical trials
Diet
Dietary Carbohydrates - administration & dosage
Dietary intake
dietary intervention
Dietary supplements
Double-Blind Method
Double-blind studies
Fatty liver
Female
Fructose
Fructose - administration & dosage
Glucose
Glucose Intolerance
glucose metabolism
Glucose tolerance
Health care facilities
hepatic steatosis
Humans
intrahepatic lipid
Lipids
Liver
Liver - metabolism
Liver diseases
Magnetic resonance spectroscopy
Male
Middle Aged
Non-alcoholic Fatty Liver Disease - prevention & control
nonalcoholic fatty liver disease
Nutrient deficiency
nutrition
Original Research Communications
Overweight
Proton magnetic resonance
randomized controlled trial
Serum lipids
Statistical analysis
Steatosis
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Beschreibung
Zusammenfassung:There is an ongoing debate on whether fructose plays a role in the development of nonalcoholic fatty liver disease. The aim of this study was to investigate the effects of fructose restriction on intrahepatic lipid (IHL) content in a double-blind randomized controlled trial using an isocaloric comparator. Between March 2017 and October 2019, 44 adult overweight individuals with a fatty liver index ≥ 60 consumed a 6-wk fructose-restricted diet (
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/nqaa332