Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment

Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment

Summary In the randomised TARGIT-A trial, risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy was non-inferior to whole-breast external beam radiotherapy, for local recurrence. In the long-term, no difference was found in any breast cancer outcome, whereas there were fe...

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Veröffentlicht in:British journal of cancer 2021-04, Vol.124 (9), p.1469-1474
Hauptverfasser: Vaidya, Jayant S., Bulsara, Max, Baum, Michael, Tobias, Jeffrey S.
Format: Artikel
Sprache:eng
Schlagworte:
692/4028/67/1347
692/700/565/485
692/700/565/545/546
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - surgery
Cancer Research
Comment
Drug Resistance
Epidemiology
Female
Humans
Intraoperative Care
Lumpectomy
Mastectomy, Segmental
Molecular Medicine
Neoplasm Recurrence, Local
Oncology
Patient-centered care
Radiation therapy
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Zusammenfassung:Summary In the randomised TARGIT-A trial, risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy was non-inferior to whole-breast external beam radiotherapy, for local recurrence. In the long-term, no difference was found in any breast cancer outcome, whereas there were fewer deaths from non-breast-cancer causes. TARGIT-IORT should be included in pre-operative consultations with eligible patients.
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-020-01233-5