A Valid Warning or Clinical Lore: an Evaluation of Safety Outcomes of Remdesivir in Patients with Impaired Renal Function from a Multicenter Matched Cohort

Per prescribing guidance, remdesivir is not recommended for SARS-CoV-2 in patients with renal disease given the absence of safety data in this patient population. This study was a multicenter, retrospective chart review of hospitalized patients with SARS-CoV-2 who received remdesivir. Safety outcome...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antimicrobial agents and chemotherapy 2021-01, Vol.65 (2)
Hauptverfasser:	Ackley, Tyler W, McManus, Dayna, Topal, Jeffrey E, Cicali, Brian, Shah, Sunish
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - administration & dosage Adenosine Monophosphate - analogs & derivatives Aged Aged, 80 and over Alanine - administration & dosage Alanine - analogs & derivatives Antiviral Agents Antiviral Agents - administration & dosage Cohort Studies COVID-19 - drug therapy COVID-19 - physiopathology COVID-19 - virology Creatinine - metabolism Humans Kidney - physiopathology Kidney Function Tests Middle Aged Renal Insufficiency - drug therapy Renal Insufficiency - physiopathology Renal Insufficiency - virology Retrospective Studies SARS-CoV-2 - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Per prescribing guidance, remdesivir is not recommended for SARS-CoV-2 in patients with renal disease given the absence of safety data in this patient population. This study was a multicenter, retrospective chart review of hospitalized patients with SARS-CoV-2 who received remdesivir. Safety outcomes were compared between patients with an estimated creatinine clearance (eCrCl) of
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.02290-20