Conjunctivitis in Dupilumab Clinical Trials for Adolescents with Atopic Dermatitis or Asthma

Background Conjunctivitis is a known comorbidity of atopic dermatitis. Dupilumab clinical trials for moderate-to-severe atopic dermatitis in adults showed a higher conjunctivitis incidence for dupilumab-treated patients than placebo-treated patients, whereas trials for uncontrolled asthma reported l...

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Veröffentlicht in:	American journal of clinical dermatology 2021, Vol.22 (1), p.101-115
Hauptverfasser:	Bansal, Ashish, Simpson, Eric L., Paller, Amy S., Siegfried, Elaine C., Blauvelt, Andrew, de Bruin-Weller, Marjolein, Corren, Jonathan, Sher, Lawrence, Guttman-Yassky, Emma, Chen, Zhen, Daizadeh, Nadia, Kamal, Mohamed A., Shumel, Brad, Mina-Osorio, Paola, Mannent, Leda, Patel, Naimish, Graham, Neil M. H., Khokhar, Faisal A., Ardeleanu, Marius
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Asthma Asthma - diagnosis Asthma - drug therapy Asthma - immunology Clinical trials Clinical Trials, Phase III as Topic Comorbidity Conjunctivitis - chemically induced Conjunctivitis - diagnosis Conjunctivitis - epidemiology Conjunctivitis - immunology Dermatitis Dermatitis, Atopic - diagnosis Dermatitis, Atopic - drug therapy Dermatitis, Atopic - immunology Dermatology Dose-Response Relationship, Drug Drug Administration Schedule Drug withdrawal Eczema Eye diseases Eye examinations Female Humans Immunotherapy Incidence Inflammatory diseases Injections, Subcutaneous Male Medicine Medicine & Public Health Monoclonal antibodies NCT NCT02414854 NCT02612454 NCT03054428 Original Original Research Article Patients Pediatrics Pharmacology/Toxicology Pharmacotherapy Placebos - administration & dosage Placebos - adverse effects Randomized Controlled Trials as Topic Regulatory approval Severity of Illness Index Teenagers Treatment Outcome
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Zusammenfassung:	Background Conjunctivitis is a known comorbidity of atopic dermatitis. Dupilumab clinical trials for moderate-to-severe atopic dermatitis in adults showed a higher conjunctivitis incidence for dupilumab-treated patients than placebo-treated patients, whereas trials for uncontrolled asthma reported lower rates for both dupilumab and placebo. Objective The objective of this study was to evaluate the incidence and severity of conjunctivitis in dupilumab clinical trials in adolescents with moderate-to-severe atopic dermatitis or uncontrolled asthma. Methods We evaluated the incidence of conjunctivitis in adolescents (aged 12 to
ISSN:	1175-0561 1179-1888 1179-1888
DOI:	10.1007/s40257-020-00577-1