The COVID-19 Pandemic in 2021: Avoiding Overdiagnosis of Anaphylaxis Risk While Safely Vaccinating the World

[...]even assuming these reported events were indeed immune-mediated, the broader population perspective must be considered. [...]even assuming PEG is the allergen, there is historical difficulty in consistently and accurately assessing anti-PEG IgE through skin testing. [...]we do not know the popu...

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Veröffentlicht in:The journal of allergy and clinical immunology in practice (Cambridge, MA) MA), 2021-04, Vol.9 (4), p.1438-1441
Hauptverfasser: Greenhawt, Matthew, Abrams, Elissa M., Oppenheimer, John, Vander Leek, Timothy K., Mack, Douglas P., Singer, Alexander G., Shaker, Marcus
Format: Artikel
Sprache:eng
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Zusammenfassung:[...]even assuming these reported events were indeed immune-mediated, the broader population perspective must be considered. [...]even assuming PEG is the allergen, there is historical difficulty in consistently and accurately assessing anti-PEG IgE through skin testing. [...]we do not know the population prevalence of PEG allergy with high enough certainty to clearly establish predictive values, or have widespread enough understanding of PEG skin testing to establish positive and negative likelihood ratios. [...]of this uncertainty, our interpretation of the value offered in clinical decision- making of a “positive” skin test response to a nonirritating concentration of PEG differs somewhat from Banerji et al.
ISSN:2213-2198
2213-2201
DOI:10.1016/j.jaip.2021.01.022