TLR2 as a Therapeutic Target in Bacterial Infection

TLR2 as a Therapeutic Target in Bacterial Infection

Toll-like receptor (TLR) 2 recognizes and responds to threats early in bacterial infections and can influence the downstream immune response to the host’s benefit or detriment. Therapeutic modulation of TLR2 signaling represents an underutilized opportunity to moderate the immune response to infecti...

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Veröffentlicht in:Trends in molecular medicine 2020-08, Vol.26 (8), p.715-717
Hauptverfasser: Simpson, Morgan E., Petri, William A.
Format: Artikel
Sprache:eng
Schlagworte:
bacterial infection
immunotherapy
innate immunity
TLR2
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Zusammenfassung:Toll-like receptor (TLR) 2 recognizes and responds to threats early in bacterial infections and can influence the downstream immune response to the host’s benefit or detriment. Therapeutic modulation of TLR2 signaling represents an underutilized opportunity to moderate the immune response to infection to promote an improved outcome for the host.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2020.05.006