Glucocorticoid maintenance therapy and severe infectious complications in ANCA-associated vasculitis: a retrospective analysis

Glucocorticoid maintenance therapy and severe infectious complications in ANCA-associated vasculitis: a retrospective analysis

To study the impact of glucocorticoid maintenance dose and treatment duration on outcomes in patients with AAV (ANCA-associated vasculitis) with emphasis on infectious complications. A total of 130 AAV patients from two German vasculitis centers diagnosed between August 2004 and January 2019 treated...

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Veröffentlicht in:Rheumatology international 2021-02, Vol.41 (2), p.431-438
Hauptverfasser: Speer, Claudius, Altenmüller-Walther, Christine, Splitthoff, Jan, Nusshag, Christian, Kälble, Florian, Reichel, Paula, Morath, Christian, Zeier, Martin, Bergner, Raoul, Schaier, Matthias
Format: Artikel
Sprache:eng
Schlagworte:
Induction therapy
Infections
Medicine
Medicine & Public Health
Observational Research
Patients
Pneumonia
Rheumatology
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Zusammenfassung:To study the impact of glucocorticoid maintenance dose and treatment duration on outcomes in patients with AAV (ANCA-associated vasculitis) with emphasis on infectious complications. A total of 130 AAV patients from two German vasculitis centers diagnosed between August 2004 and January 2019 treated with cyclophosphamide and glucocorticoids for induction therapy and glucocorticoids for maintenance therapy were retrospectively enrolled. We investigated the influence of glucocorticoid maintenance therapy on patient survival, time to relapse, kidney function, infectious complications and irreversible physical damage. The patients were divided into the following groups: patients treated according to the predefined reduction scheme (
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-020-04752-9