Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2

This review describes the sex and gender differences in COVID-19 presentation, treatment, and outcomes. We discuss the differences between the sexes in susceptibility to infection, the role of sex chromosomes on the body's immunologic response and the influence of hormones on the body's re...

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Veröffentlicht in:	Clinical therapeutics 2021-03, Vol.43 (3), p.557-571.e1
Hauptverfasser:	Wolfe, Jeannette, Safdar, Basmah, Madsen, Tracy E., Sethuraman, Kinjal N., Becker, Bruce, Greenberg, Marna Rayl, McGregor, Alyson J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes Complications Coronaviruses COVID Review COVID-19 COVID-19 - epidemiology COVID-19 - therapy Female Gender Hormones Humans Immunology Infections long haulers Male Medical research Mortality Sars Cov2 SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome coronavirus 2 sex and gender based medicine Sex chromosomes Sex differences Sex Factors sex-disaggregated analysis Viruses
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Beschreibung
Zusammenfassung:	This review describes the sex and gender differences in COVID-19 presentation, treatment, and outcomes. We discuss the differences between the sexes in susceptibility to infection, the role of sex chromosomes on the body's immunologic response and the influence of hormones on the body's response to the virus. Additionally, the sex differences in clinical and laboratory presentation, complications of infection and outcomes, as well as differences in response to treatment and prevention are reviewed.
ISSN:	0149-2918 1879-114X 1879-114X
DOI:	10.1016/j.clinthera.2021.01.015