Non-canonical cholinergic anti-inflammatory pathway in IBD
Vagus nerve stimulation has shown promise in treating inflammatory bowel disease. A new study identifies a hepatic vagal branch pathway necessary to maintain colonic immune cell homeostasis in experimental colitis, challenging the dogma that an anti-inflammatory reflex requires an intact spleen and...
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| Veröffentlicht in: | Nature reviews. Gastroenterology & hepatology 2020-11, Vol.17 (11), p.651-652 |
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| container_issue | 11 |
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| container_title | Nature reviews. Gastroenterology & hepatology |
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| creator | de Araujo, Alan de Lartigue, Guillaume |
| description | Vagus nerve stimulation has shown promise in treating inflammatory bowel disease. A new study identifies a hepatic vagal branch pathway necessary to maintain colonic immune cell homeostasis in experimental colitis, challenging the dogma that an anti-inflammatory reflex requires an intact spleen and that α7-nicotinic receptor agonists are a panacea for inflammatory conditions. |
| doi_str_mv | 10.1038/s41575-020-0356-y |
| format | Article |
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| subjects | 631/250/256 631/378/1959/1315/1951 Biomedicine Brain Care and treatment Cholinergic mechanisms Colitis Development and progression Gastroenterology Gastrointestinal Microbiome Health aspects Hepatology Homeostasis Humans Inflammation Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Intestine Liver Medicine Medicine & Public Health Neuroimmunomodulation News & Views news-and-views Physiological aspects Spleen T cells T-Lymphocytes, Regulatory Vagus nerve Vagus nerve stimulation |
| title | Non-canonical cholinergic anti-inflammatory pathway in IBD |
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