Non-canonical cholinergic anti-inflammatory pathway in IBD

Vagus nerve stimulation has shown promise in treating inflammatory bowel disease. A new study identifies a hepatic vagal branch pathway necessary to maintain colonic immune cell homeostasis in experimental colitis, challenging the dogma that an anti-inflammatory reflex requires an intact spleen and...

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Veröffentlicht in:	Nature reviews. Gastroenterology & hepatology 2020-11, Vol.17 (11), p.651-652
Hauptverfasser:	de Araujo, Alan, de Lartigue, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/256 631/378/1959/1315/1951 Biomedicine Brain Care and treatment Cholinergic mechanisms Colitis Development and progression Gastroenterology Gastrointestinal Microbiome Health aspects Hepatology Homeostasis Humans Inflammation Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Intestine Liver Medicine Medicine & Public Health Neuroimmunomodulation News & Views news-and-views Physiological aspects Spleen T cells T-Lymphocytes, Regulatory Vagus nerve Vagus nerve stimulation
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Beschreibung
Zusammenfassung:	Vagus nerve stimulation has shown promise in treating inflammatory bowel disease. A new study identifies a hepatic vagal branch pathway necessary to maintain colonic immune cell homeostasis in experimental colitis, challenging the dogma that an anti-inflammatory reflex requires an intact spleen and that α7-nicotinic receptor agonists are a panacea for inflammatory conditions.
ISSN:	1759-5045 1759-5053
DOI:	10.1038/s41575-020-0356-y