Efficacy of L-Carnitine for Dilated Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials

Background. L-carnitine mediates the utilization of fatty acids and glucose in the myocardium. The potential of L-carnitine in managing dilated cardiomyopathy (DCM) in patients has been extensively reported, with additional benefits. Objective. This meta-analysis purposed to explore the clinical eff...

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Veröffentlicht in:	BioMed research international 2021, Vol.2021, p.9491615-11
Hauptverfasser:	Weng, Yayun, Zhang, Shuo, Huang, Wei, Xie, Xianze, Ma, Zhiyuan, Fan, Qiaomei
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain natriuretic peptide Cardiac arrhythmia Cardiac output Cardiomyopathy Cardiomyopathy, Dilated Cardiomyopathy, Dilated - drug therapy Cardiovascular research Care and treatment Carnitine Carnitine - therapeutic use Classification Clinical trials Dilated cardiomyopathy Documents Dosage and administration Drug dosages Drug therapy Evaluation Fatty acids Fatty Acids - metabolism Glucose - metabolism Growth factors Heart Heart failure Heterogeneity Humans Levocarnitine Medical prognosis Meta-analysis Metabolism Mortality Myocardium Myocardium - metabolism Natriuretic Peptide, Brain - metabolism Oral administration Physiological aspects Properties Randomized Controlled Trials as Topic Research Design Review Risk Stroke Volume Testing Therapy Transforming Growth Factor beta1 - metabolism Transforming growth factor-b Transforming growth factor-b1 Vasoactive intestinal peptide Ventricle Ventricular Function, Left
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Zusammenfassung:	Background. L-carnitine mediates the utilization of fatty acids and glucose in the myocardium. The potential of L-carnitine in managing dilated cardiomyopathy (DCM) in patients has been extensively reported, with additional benefits. Objective. This meta-analysis purposed to explore the clinical efficacy of L-carnitine therapy on DCM patients. Methods. We searched publications up to May 2020 from several databases including PubMed, Embase, Cochrane Library, Chinese Biomedical (CBM) database, Chinese Science and Technology Periodicals database (VIP), Chinese National Knowledge Infrastructure (CNKI) database, and Wanfang database. Subsequently, publications that met the inclusion criteria were systematically evaluated by two independent reviewers. Results. A total of 23 RCTs conducted in China with 1455 DCM patients were included in this study. In the meta-analysis, L-carnitine therapy was associated with a considerable improvement in the overall efficacy (RR=1.28, 95% CI (1.21-1.36), P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2021/9491615