Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane

An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibits a broad reaction scope, a simple operation and without the need of any expensive transition-metal catalyst,...

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Veröffentlicht in:Beilstein journal of organic chemistry 2021-01, Vol.17 (1), p.89-96
Hauptverfasser: Karuo, Yukiko, Kametani, Ayaka, Tarui, Atsushi, Sato, Kazuyuki, Kawai, Kentaro, Omote, Masaaki
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Sprache:eng
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Zusammenfassung:An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibits a broad reaction scope, a simple operation and without the need of any expensive transition-metal catalyst, highly toxic or corrosive reagents. Notably, we demonstrate the potential utility of halothane for the synthesis of aryl -difluoroalkyl ethers containing the bromochloromethyl group.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.17.9