Effects of IL‐18 on the proliferation and steroidogenesis of bovine theca cells: Possible roles in the pathogenesis of polycystic ovary syndrome

Interleukin 18 (IL‐18) is a pleiotropic pro‐inflammatory cytokine and is associated with arrested follicle development and anovulation which are the typical pathological changes of PCOS. Theca cells (TCs) have a key role in follicular growth and atresia. But whether IL‐18 can directly affect ovarian...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-01, Vol.25 (2), p.1128-1139
Hauptverfasser:	Zhang, Hong yuan, Zhu, Fu fan, Zhu, Ying jun, Hu, Yuan jing, Chen, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Androstenedione Animals Antibodies Biosynthesis bovine Cattle Cell culture Cell growth Cell proliferation Cell Proliferation - drug effects Cell Separation Cholesterol Cytochrome Cytokines Dysplasia Enzymes Female Follicles Folliculogenesis Gene Expression Regulation - drug effects Gene regulation IL‐18 Immunohistochemistry Inflammation Interleukin 18 Interleukin-18 - pharmacology JNK Mitogen-Activated Protein Kinases - metabolism Laboratories Luteinizing Hormone - pharmacology Original Ovaries Pathogenesis Polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - pathology proliferation Proteins Receptors, Interleukin-18 - metabolism Reproductive status RNA, Messenger - genetics RNA, Messenger - metabolism Steroidogenesis Steroids Steroids - biosynthesis Theca theca cells Theca Cells - metabolism Tumor necrosis factor-TNF
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