Effects of IL‐18 on the proliferation and steroidogenesis of bovine theca cells: Possible roles in the pathogenesis of polycystic ovary syndrome

Interleukin 18 (IL‐18) is a pleiotropic pro‐inflammatory cytokine and is associated with arrested follicle development and anovulation which are the typical pathological changes of PCOS. Theca cells (TCs) have a key role in follicular growth and atresia. But whether IL‐18 can directly affect ovarian...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-01, Vol.25 (2), p.1128-1139
Hauptverfasser:	Zhang, Hong yuan, Zhu, Fu fan, Zhu, Ying jun, Hu, Yuan jing, Chen, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Androstenedione Animals Antibodies Biosynthesis bovine Cattle Cell culture Cell growth Cell proliferation Cell Proliferation - drug effects Cell Separation Cholesterol Cytochrome Cytokines Dysplasia Enzymes Female Follicles Folliculogenesis Gene Expression Regulation - drug effects Gene regulation IL‐18 Immunohistochemistry Inflammation Interleukin 18 Interleukin-18 - pharmacology JNK Mitogen-Activated Protein Kinases - metabolism Laboratories Luteinizing Hormone - pharmacology Original Ovaries Pathogenesis Polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - pathology proliferation Proteins Receptors, Interleukin-18 - metabolism Reproductive status RNA, Messenger - genetics RNA, Messenger - metabolism Steroidogenesis Steroids Steroids - biosynthesis Theca theca cells Theca Cells - metabolism Tumor necrosis factor-TNF
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Zusammenfassung:	Interleukin 18 (IL‐18) is a pleiotropic pro‐inflammatory cytokine and is associated with arrested follicle development and anovulation which are the typical pathological changes of PCOS. Theca cells (TCs) have a key role in follicular growth and atresia. But whether IL‐18 can directly affect ovarian TCs function is unknown. Therefore, the objective of this study was to determine the effect of IL‐18 on proliferation and steroidogenesis of bovine TCs and to explore the biological effect of IL‐18 on folliculogenesis. This work revealed that at 300‐1000 pg/mL, IL‐18 led to a time‐ and dose‐dependently increase in cell proliferation (P
ISSN:	1582-1838 1582-4934
DOI:	10.1111/jcmm.16179