COVID‐19 lessons from the dish: Dissecting CNS manifestations through brain organoids

COVID‐19 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of SARS‐CoV‐2’s neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS‐CoV‐2 infection and uncover its Tau‐related neurotoxicity. Graphical Abstract Recent work reports consequences of SARS‐CoV‐2 infection in cerebral 3D in vitro models and highlights neurons as primary target cells.