Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Eastern equine encephalitis virus (EEEV) is one of the most virulent viruses endemic to North America. No licensed vaccines or antiviral therapeutics are available to combat this infection, which has recently shown an increase in human cases. Here, we characterize human monoclonal antibodies (mAbs)...

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Veröffentlicht in:	Cell 2020-12, Vol.183 (7), p.1884-1900.e23
Hauptverfasser:	Williamson, Lauren E., Gilliland, Theron, Yadav, Pramod K., Binshtein, Elad, Bombardi, Robin, Kose, Nurgun, Nargi, Rachel S., Sutton, Rachel E., Durie, Clarissa L., Armstrong, Erica, Carnahan, Robert H., Walker, Lauren M., Kim, Arthur S., Fox, Julie M., Diamond, Michael S., Ohi, Melanie D., Klimstra, William B., Crowe, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult aerosol Aerosols - administration & dosage Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antigens, Viral - immunology Cryoelectron Microscopy Disease Models, Animal Eastern equine encephalitis Encephalitis Virus, Eastern Equine - immunology Encephalitis Virus, Eastern Equine - ultrastructure Encephalomyelitis, Equine - immunology Encephalomyelitis, Equine - prevention & control Encephalomyelitis, Equine - virology Epitopes - chemistry Female Glycoproteins - immunology human antibodies Humans Mice Models, Molecular monoclonal Mutagenesis - genetics Neutralization Tests neutralizing prophylaxis Protein Binding Protein Domains Recombinant Proteins - immunology Sindbis Virus - immunology therapy Virion - immunology Virion - ultrastructure Virus Internalization
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Beschreibung
Zusammenfassung:	Eastern equine encephalitis virus (EEEV) is one of the most virulent viruses endemic to North America. No licensed vaccines or antiviral therapeutics are available to combat this infection, which has recently shown an increase in human cases. Here, we characterize human monoclonal antibodies (mAbs) isolated from a survivor of natural EEEV infection with potent (
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2020.11.011