Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

Abstract Background Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate. The complement system is an important component of innate immunity and can stimulate inflammation, but its role in C...

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Veröffentlicht in:The Journal of infectious diseases 2021-02, Vol.223 (2), p.214-224
Hauptverfasser: de Nooijer, Aline H, Grondman, Inge, Janssen, Nico A F, Netea, Mihai G, Willems, Loek, van de Veerdonk, Frank L, Giamarellos-Bourboulis, Evangelos J, Toonen, Erik J M, Joosten, Leo A B
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Clinical outcomes
Complement activation
Complement Activation - immunology
Complement C3c - immunology
Complement component C3a
Complement component C3c
Coronaviruses
COVID-19
COVID-19 - immunology
COVID-19 - mortality
Cytokines - blood
Disease Progression
Female
Humans
Immune response
Immunity, Innate
Inflammation
Inflammation - immunology
Innate immunity
Longitudinal Studies
Major and Brief Reports
Male
Middle Aged
Mortality
Netherlands - epidemiology
Patients
Prospective Studies
Respiratory Distress Syndrome - immunology
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Thromboembolism
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Zusammenfassung:Abstract Background Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate. The complement system is an important component of innate immunity and can stimulate inflammation, but its role in COVID-19 is unknown. Methods A prospective, longitudinal, single center study was performed in hospitalized patients with COVID-19. Plasma concentrations of complement factors C3a, C3c, and terminal complement complex (TCC) were assessed at baseline and during hospital admission. In parallel, routine laboratory and clinical parameters were collected from medical files and analyzed. Results Complement factors C3a, C3c, and TCC were significantly increased in plasma of patients with COVID-19 compared with healthy controls (P 
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiaa646