Residual endogenous insulin secretion in Japanese children with type 1A diabetes

We investigated serum C-peptide immunoreactivity (CPR) levels in registered data from a multi-center collaborative nationwide type 1 diabetes study. The CPR levels were obtained from 576 and 409 children during the early registration (2013/2014) and late observation (2016/2017) periods, respectively...

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Veröffentlicht in:Clinical Pediatric Endocrinology 2021, Vol.30(1), pp.27-33
Hauptverfasser: Sugihara, Shigetaka, Kikuchi, Toru, Urakami, Tatsuhiko, Yokota, Ichiro, Kikuchi, Nobuyuki, Kawamura, Tomoyuki, Amemiya, Shin, on behalf of the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)
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Sprache:eng
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Zusammenfassung:We investigated serum C-peptide immunoreactivity (CPR) levels in registered data from a multi-center collaborative nationwide type 1 diabetes study. The CPR levels were obtained from 576 and 409 children during the early registration (2013/2014) and late observation (2016/2017) periods, respectively. The percentages of children with a CPR < 0.1 or < 0.3 ng/mL increased according to the duration since diagnosis. Among patients with 5 or more years since diagnosis, 69% had a CPR < 0.1 and 95% had a CPR < 0.3 in the early registration period. A significant negative correlation was observed between the HbA1c and the CPR levels, and the HbA1c levels were significantly higher among children with a CPR < 0.1 or < 0.3 than among those with a CPR ≥ 0.6 ng/mL. During the late observation period, the prevalence of a CPR < 0.1 ng/mL was 88% among long-standing patients and 77% among patients aged 18–20 yr. Regarding the characteristics of “Responders” with a sustained CPR ≥ 0.6 ng/mL at 5 or more years since diagnosis, six of the seven were adolescent females; five of the seven had an HLA DR4-DQ4 haplotype. When type 1A diabetes mellitus (T1AD) children transit to adult care centers, most of them may have some difficulty in glycemic control because of the depleted endogenous insulin.
ISSN:0918-5739
1347-7358
DOI:10.1297/cpe.30.27