Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

A study which examines whether urinary eicosanoid metabolites can direct asthma phenotyping is presented. Cysteinyl leukotrienes (CysLTs), urinary metabolites of prostaglandins (PGs) and isoprostanes were quantified in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes) study. Monitoring of urinary eicosanoids introduces a new noninvasive approach for molecular phenotyping of adolescent and adult asthma and can identify type 2 (T2) asthma.