Carbohydrate‐induced weight gain models for diabetes research: Contribution of incretins and parasympathetic signal

[...]the mode of administration of the sucrose is considered to differentially affect sensitivity to sweet taste, postprandial glucose and fructose levels, and the satiety signal to the hypothalamus. Furthermore, ST‐induced bodyweight gain and insulin secretion under the ad libitum‐fed condition are enhanced in ST‐fed Kir6.2KO. [...]the KATP channel in β‐cells is not required for carbohydrate‐induced bodyweight gain (Figure 2) 3. [...]ST feeding failed to significantly increase BCM and islet number in Kir6.2KO mice. [...]the parasympathetic signal is insufficient to induce β‐cell proliferation under ST feeding, and functional KATP channels might be required for feeding‐induced β‐cell proliferation (Figure 2).