Blood pressure after treatment with sodium–glucose cotransporter 2 inhibitors influences renal composite outcome: Analysis using propensity score‐matched models

Aims/Introduction Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve renal outcome in patients with type 2 diabetes mellitus, but the mechanism is not fully understood. The aim of this retrospective study was to assess the association of achieved blood pressure with renal outcomes in Japanes...

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Veröffentlicht in:	Journal of Cutaneous Immunology and Allergy 2021-01, Vol.12 (1), p.74-81
Hauptverfasser:	Kobayashi, Kazuo, Toyoda, Masao, Hatori, Nobuo, Furuki, Takayuki, Sakai, Hiroyuki, Umezono, Tomoya, Ito, Shun, Suzuki, Daisuke, Takeda, Hiroshi, Minagawa, Fuyuki, Degawa, Hisakazu, Yamamoto, Hareaki, Machimura, Hideo, Chin, Keiichi, Hishiki, Toshimasa, Takihata, Masahiro, Aoyama, Kouta, Umezawa, Shinichi, Minamisawa, Kohsuke, Aoyama, Togo, Hamada, Yoshiro, Suzuki, Yoshiro, Hayashi, Masahiro, Hatori, Yutaka, Sato, Kazuyoshi, Miyakawa, Masaaki, Tamura, Kouichi, Kanamori, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Albumin Analysis Bias Biomarkers - analysis Blood Glucose - analysis Blood Pressure Chronic kidney failure Clinical medicine Creatinine Dapagliflozin Dextrose Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetic Cardiomyopathies - etiology Diabetic Cardiomyopathies - prevention & control Diabetic Nephropathies - drug therapy Diabetic Nephropathies - etiology Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic nephropathy Drug therapy Female Follow-Up Studies Glomerular Filtration Rate Glucose Glycated Hemoglobin - analysis Humans Hypertension Kidney diseases Male Middle Aged Original Patient outcomes Prognosis Propensity Score Regression analysis Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Retrospective Studies Sodium-glucose cotransporter Sodium-Glucose Transporter 2 Inhibitors - therapeutic use Sodium–glucose cotransporter 2 Inhibitors Type 2 diabetes
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Zusammenfassung:	Aims/Introduction Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve renal outcome in patients with type 2 diabetes mellitus, but the mechanism is not fully understood. The aim of this retrospective study was to assess the association of achieved blood pressure with renal outcomes in Japanese type 2 diabetes mellitus patients with chronic kidney disease. Materials and Methods We assessed 624 Japanese type 2 diabetes mellitus patients with chronic kidney disease taking SGLT2i for >1 year. The patients were classified as those with post‐treatment mean arterial pressure (MAP) of ≥92 mmHg (n = 344) and those with MAP of
ISSN:	2040-1116 2040-1124
DOI:	10.1111/jdi.13318