Stewardship program on carbapenem prescriptions in a tertiary hospital for adults and children in France: a cohort study

Antimicrobial stewardship programs aim at reducing the overuse of broad-spectrum antibiotics such as carbapenems, but their impact remains unclear. We compared the use of carbapenems between paediatric and adult subjects admitted to a French tertiary hospital and described the intervention of an antibiotic stewardship team (AST). As part of AST routine activity, all adult and paediatric patients receiving carbapenems are identified in real time using a computer-generated alert system and reviewed by the AST. Data associated with carbapenem prescriptions were extracted for 2 years (2014–2015) and were compared between paediatric and adult wards. Prescription appropriateness (i.e. no clinically suitable narrower spectrum alternative to carbapenem for de-escalation) and AST intervention were analysed. In total, 775 carbapenem prescriptions for 291 children and 262 adults were included. Most patients (95%) had a comordity and 52% had known recent carriage of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBLE). Most carbapenem prescriptions came from intensive care units ( n = 269, 35%) and were initiated for urinary tract ( n = 200, 27%), sepsis ( n = 181, 25%), and lung ( n = 153, 21%) infections. Carbapenems were initiated empirically in 537 (70%) cases, and an organism was isolated in 523 (67%) cases. Among the isolated organisms, 47% ( n = 246) were ESBLE and 90% ( n = 468) were susceptible to carbapenems, but an alternative existed in 61% ( n = 320) of cases according to antibiotic susceptibility testing. Among prescriptions reviewed by the AST, 39% ( n = 255) were considered non-appropriate and led to either antibiotic discontinuation ( n = 47, 7%) or de-escalation ( n = 208, 32%). Non-appropriate prescriptions were more frequent in paediatric wards ( p = 0.01) and in microbiologically documented infections ( p = 0.013), and less observed in immunocompromised patients ( p = 0.009) or with a known ESBLE carriage ( p