Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era

The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012–June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reacti...

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Veröffentlicht in:	Epidemiology and infection 2020-11, Vol.148, p.e279-37, Article 0950268820002708
Hauptverfasser:	Izquierdo, C., Ciruela, P., Hernández, S., García-García, J. J., Esteva, C., Moraga-Llop, F., Díaz-Conradi, A., Martínez-Osorio, J., Solé-Ribalta, A., de Sevilla, M. F., González-Peris, S., Codina, G., Planes, A. M., Uriona, S., Campins, M., Muñoz-Almagro, C., Salleras, L., Domínguez, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age groups Anti-Bacterial Agents - pharmacology Antibiotics Antiinfectives and antibacterials Antimicrobial agents Bacteremia Cefotaxime Cellulitis Child Child, Preschool Children Chronic illnesses Confidence intervals Congenital diseases Deoxyribonucleic acid DNA Drug Resistance, Bacterial Epidemiology Fatalities Female Humans Immunization Infant Infectious Diseases Intensive care Life Sciences & Biomedicine Male Meningitis Original Paper Pancreatitis Pediatrics Penicillin Pneumococcal Infections - microbiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - immunology Pneumonia Polymerase chain reaction Prospective Studies Public, Environmental & Occupational Health Real time Science & Technology Seasons Sepsis Serogroup Serotypes Streptococcus infections Streptococcus pneumoniae - classification Susceptibility Vaccines
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Beschreibung
Zusammenfassung:	The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012–June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reaction (PCR). Demographic, microbiological and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI). Of the 253 cases, 34.4% were aged
ISSN:	0950-2688 1469-4409
DOI:	10.1017/S0950268820002708