Esaxerenone (CS-3150) in Patients with Type 2 Diabetes and Microalbuminuria (ESAX-DN): Phase 3 Randomized Controlled Clinical Trial

Diabetic kidney disease is an important complication of type 2 diabetes. In a phase 2b study, adding esaxerenone to renin-angiotensin system inhibitors dose dependently reduced the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and microalbuminuria. This 52-week phase 3 study f...

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Veröffentlicht in:	Clinical journal of the American Society of Nephrology 2020-12, Vol.15 (12), p.1715-1727
Hauptverfasser:	Ito, Sadayoshi, Kashihara, Naoki, Shikata, Kenichi, Nangaku, Masaomi, Wada, Takashi, Okuda, Yasuyuki, Sawanobori, Tomoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Albuminuria - diagnosis Albuminuria - drug therapy Albuminuria - etiology Albuminuria - physiopathology Biomarkers - urine Creatinine - urine Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Female Humans Japan Kidney - drug effects Kidney - physiopathology Male Middle Aged Mineralocorticoid Receptor Antagonists - adverse effects Mineralocorticoid Receptor Antagonists - therapeutic use Original Pyrroles - adverse effects Pyrroles - therapeutic use Remission Induction Risk Factors Sulfones - adverse effects Sulfones - therapeutic use Time Factors Treatment Outcome
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Zusammenfassung:	Diabetic kidney disease is an important complication of type 2 diabetes. In a phase 2b study, adding esaxerenone to renin-angiotensin system inhibitors dose dependently reduced the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and microalbuminuria. This 52-week phase 3 study further investigated the effects of esaxerenone on the urinary albumin-to-creatinine ratio in this patient group. In this multicenter, randomized, double-blind study, patients with type 2 diabetes and a urinary albumin-to-creatinine ratio of 45 to
ISSN:	1555-9041 1555-905X 1555-905X
DOI:	10.2215/CJN.06870520