Scavenger receptors

Scavenger receptors (SRs) are a large family of cell-surface receptors that are diverse in their structure and biological function and are divided into different classes. SRs can bind to a range of ligands and enhance the elimination of altered-self or non-self targets. The functional mechanisms that lead to their clearance of harmful substances involve phagocytosis, endocytosis, adhesion, and signaling. In this Primer, Alquraini and El Khoury discuss key features of scavenger receptor biology, including their structural properties, ligands and functions, and also review the role of these receptors in innate immunity and disease.