Chronic lymphocytic leukemia increases the pool of peripheral blood hematopoietic stem cells and skews differentiation
•CLL increases the pool of ST-HSCs in the peripheral blood.•Differentiation of CLL-derived peripheral blood HSPCs is skewed toward the myeloid lineage. [Display omitted]
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| Veröffentlicht in: | Blood advances 2020-12, Vol.4 (24), p.6310-6314 |
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| container_end_page | 6314 |
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| container_issue | 24 |
| container_start_page | 6310 |
| container_title | Blood advances |
| container_volume | 4 |
| creator | Santoro, Antonella Andrei, Camelia Bryant, Clare Calderbank, Emily Wray, Alison Baxter, Joanna E. Godfrey, Anna Laurenti, Elisa Ringshausen, Ingo |
| description | •CLL increases the pool of ST-HSCs in the peripheral blood.•Differentiation of CLL-derived peripheral blood HSPCs is skewed toward the myeloid lineage.
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| doi_str_mv | 10.1182/bloodadvances.2020002863 |
| format | Article |
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[Display omitted]</description><subject>Cell Differentiation</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hematopoietic Stem Cells</subject><subject>Humans</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell</subject><subject>Stimulus Report</subject><issn>2473-9529</issn><issn>2473-9537</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1P3DAQtapWBW35C8jHXhb8sU7iSyVYFYqExAXOlj8mxCWJU9u71f57HJYucOppRpr33ryZhxCm5IzShp2bPgSn3VaPFtIZI4wQwpqKf0LHbFXzpRS8_nzomTxCJyn9LiBaV1xI9hUdcc4FpUwco-26i2H0Fve7YeqC3eW5h80TDF5jP9oIOkHCuQM8hdDj0OIJop86iLrHL15wB4POYQoeZnbKMGALfZ-wHh1OT_A3YefbFiKM2evsw_gNfWl1n-DktS7Qw9XP-_Wv5e3d9c364nZpxUrkpTTCCO2cra0BYNY43ljNrWGMVJLR1YprXtGmYrVxDQPCpJMGbKupbCRv-AL92OtOGzOAs8VAsa2m6Acddyporz5ORt-px7BVdS2qWWKBvr8KxPBnAymrwaf5OD1C2CRVvswoJYyTAm32UBtDShHawxpK1Jyc-pCcekuuUE_f2zwQ_-VUAJd7AJRnbT1ElayHIuN8BJuVC_7_W54BM0u0MA</recordid><startdate>20201222</startdate><enddate>20201222</enddate><creator>Santoro, Antonella</creator><creator>Andrei, Camelia</creator><creator>Bryant, Clare</creator><creator>Calderbank, Emily</creator><creator>Wray, Alison</creator><creator>Baxter, Joanna E.</creator><creator>Godfrey, Anna</creator><creator>Laurenti, Elisa</creator><creator>Ringshausen, Ingo</creator><general>Elsevier Inc</general><general>American Society of Hematology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9917-9092</orcidid><orcidid>https://orcid.org/0000-0002-1012-888X</orcidid><orcidid>https://orcid.org/0000-0002-5946-5238</orcidid><orcidid>https://orcid.org/0000-0002-7247-311X</orcidid><orcidid>https://orcid.org/0000-0002-1166-6508</orcidid></search><sort><creationdate>20201222</creationdate><title>Chronic lymphocytic leukemia increases the pool of peripheral blood hematopoietic stem cells and skews differentiation</title><author>Santoro, Antonella ; Andrei, Camelia ; Bryant, Clare ; Calderbank, Emily ; Wray, Alison ; Baxter, Joanna E. ; Godfrey, Anna ; Laurenti, Elisa ; Ringshausen, Ingo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-9b5b5addc7cbee2cbd38ca3cb2206921443a3618627bd82e029d9becfa1989383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cell Differentiation</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hematopoietic Stem Cells</topic><topic>Humans</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell</topic><topic>Stimulus Report</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santoro, Antonella</creatorcontrib><creatorcontrib>Andrei, Camelia</creatorcontrib><creatorcontrib>Bryant, Clare</creatorcontrib><creatorcontrib>Calderbank, Emily</creatorcontrib><creatorcontrib>Wray, Alison</creatorcontrib><creatorcontrib>Baxter, Joanna E.</creatorcontrib><creatorcontrib>Godfrey, Anna</creatorcontrib><creatorcontrib>Laurenti, Elisa</creatorcontrib><creatorcontrib>Ringshausen, Ingo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Blood advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santoro, Antonella</au><au>Andrei, Camelia</au><au>Bryant, Clare</au><au>Calderbank, Emily</au><au>Wray, Alison</au><au>Baxter, Joanna E.</au><au>Godfrey, Anna</au><au>Laurenti, Elisa</au><au>Ringshausen, Ingo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic lymphocytic leukemia increases the pool of peripheral blood hematopoietic stem cells and skews differentiation</atitle><jtitle>Blood advances</jtitle><addtitle>Blood Adv</addtitle><date>2020-12-22</date><risdate>2020</risdate><volume>4</volume><issue>24</issue><spage>6310</spage><epage>6314</epage><pages>6310-6314</pages><issn>2473-9529</issn><eissn>2473-9537</eissn><abstract>•CLL increases the pool of ST-HSCs in the peripheral blood.•Differentiation of CLL-derived peripheral blood HSPCs is skewed toward the myeloid lineage.
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| fulltext | fulltext |
| identifier | ISSN: 2473-9529 |
| ispartof | Blood advances, 2020-12, Vol.4 (24), p.6310-6314 |
| issn | 2473-9529 2473-9537 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Cell Differentiation Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Humans Leukemia, Lymphocytic, Chronic, B-Cell Stimulus Report |
| title | Chronic lymphocytic leukemia increases the pool of peripheral blood hematopoietic stem cells and skews differentiation |
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