Chronic lymphocytic leukemia increases the pool of peripheral blood hematopoietic stem cells and skews differentiation

Chronic lymphocytic leukemia increases the pool of peripheral blood hematopoietic stem cells and skews differentiation

•CLL increases the pool of ST-HSCs in the peripheral blood.•Differentiation of CLL-derived peripheral blood HSPCs is skewed toward the myeloid lineage. [Display omitted]

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Bibliographische Detailangaben
Veröffentlicht in:Blood advances 2020-12, Vol.4 (24), p.6310-6314
Hauptverfasser: Santoro, Antonella, Andrei, Camelia, Bryant, Clare, Calderbank, Emily, Wray, Alison, Baxter, Joanna E., Godfrey, Anna, Laurenti, Elisa, Ringshausen, Ingo
Format: Artikel
Sprache:eng
Schlagworte:
Cell Differentiation
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Stimulus Report
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Zusammenfassung:•CLL increases the pool of ST-HSCs in the peripheral blood.•Differentiation of CLL-derived peripheral blood HSPCs is skewed toward the myeloid lineage. [Display omitted]
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2020002863