Outcomes after heart transplantation for al compared to ATTR cardiac amyloidosis

Outcomes after heart transplantation for al compared to ATTR cardiac amyloidosis

Light‐chain (AL) cardiac amyloidosis (CA) has a worse prognosis than transthyretin (ATTR) CA. In this single‐center study, we compared post‐heart transplant (OHT, orthotopic heart transplantation) survival for AL and ATTR amyloidosis, hypothesizing that these differences would persist post‐OHT. Thir...

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Veröffentlicht in:Clinical transplantation 2020-10, Vol.34 (10), p.e14028-e14028
Hauptverfasser: Griffin, Jan M., Chiu, Leonard, Axsom, Kelly M., Bijou, Rachel, Clerkin, Kevin J., Colombo, Paolo, Cuomo, Margaret O., De Los Santos, Jeffeny, Fried, Justin A., Goldsmith, Jeff, Habal, Marlena, Haythe, Jennifer, Helmke, Stephen, Horn, Evelyn M., Latif, Farhana, Hi Lee, Sun, Lin, Edward F., Naka, Yoshifumi, Raikhelkar, Jayant, Restaino, Susan, Sayer, Gabriel T., Takayama, Hiroo, Takeda, Koji, Teruya, Sergio, Topkara, Veli, Tsai, Emily J., Uriel, Nir, Yuzefpolskaya, Melana, Farr, Maryjane A., Maurer, Mathew S.
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Sprache:eng
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Zusammenfassung:Light‐chain (AL) cardiac amyloidosis (CA) has a worse prognosis than transthyretin (ATTR) CA. In this single‐center study, we compared post‐heart transplant (OHT, orthotopic heart transplantation) survival for AL and ATTR amyloidosis, hypothesizing that these differences would persist post‐OHT. Thirty‐nine patients with CA (AL, n = 18; ATTR, n = 21) and 1023 non‐amyloidosis subjects undergoing OHT were included. Cox proportional hazards modeling was used to evaluate the impact of amyloid subtype and era (early era: from 2001 to 2007; late era: from 2008 to 2018) on survival post‐OHT. Survival for non‐amyloid patients was greater than ATTR ( P  = .034) and AL ( P  
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.14028