Supraglottic Lung Microbiome Taxa Are Associated with Pulmonary Abnormalities in an HIV Longitudinal Cohort

In this work, the authors investigated the associations between lung function, inflammation, and lung microbiome dysbiosis in an HIV-positive population with relatively advanced disease who were studied at baseline and over a 1-year follow-up. Our study population consisted of 30 HIV-infected, treatment-naive adults who underwent analysis of lung inflammatory mediators and pulmonary function testing before antiretroviral therapy (ART) and again at 4 weeks and I year after starting ART. As previously reported, these subjects had advanced HIV disease at baseline (median and interquartile range of CIM is 280 and 92-385) and had sustained viral control and improved CIM counts after starting ART. Forty-eight genera had a relative abundance >2% and were included in this analysis. Taxa were then classified -is either IU'1 or SIM' based on previous classificatoon. Taxa not classified in these prior reports were included in the SPT group if they were known common oropharyngeal organisms.