Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study

Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study

Abstract Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cl...

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Veröffentlicht in:Open forum infectious diseases 2020-12, Vol.7 (12), p.ofaa538
Hauptverfasser: Liu, Jiajun, Tong, Steven Y C, Davis, Joshua S, Rhodes, Nathaniel J, Scheetz, Marc H
Format: Artikel
Sprache:eng
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Brief Reports
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Zusammenfassung:Abstract Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofaa538