A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

Hospitalized adults with severe Covid-19 pneumonia were randomly assigned in a 2:1 ratio to receive convalescent plasma or placebo. At 30 days, no significant difference in clinical status was noted between the two groups. Overall mortality was 11.43% with placebo and 10.96% with convalescent plasma...

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Veröffentlicht in:	The New England journal of medicine 2021-02, Vol.384 (7), p.619-629
Hauptverfasser:	Simonovich, Ventura A, Burgos Pratx, Leandro D, Scibona, Paula, Beruto, María V, Vallone, Marcelo G, Vázquez, Carolina, Savoy, Nadia, Giunta, Diego H, Pérez, Lucía G, Sánchez, Marisa del L, Gamarnik, Andrea Vanesa, Ojeda, Diego S, Santoro, Diego M, Camino, Pablo J, Antelo, Sebastian, Rainero, Karina, Vidiella, Gabriela P, Miyazaki, Erica A, Cornistein, Wanda, Trabadelo, Omar A, Ross, Fernando M, Spotti, Mariano, Funtowicz, Gabriel, Scordo, Walter E, Losso, Marcelo H, Ferniot, Inés, Pardo, Pablo E, Rodriguez, Eulalia, Rucci, Pablo, Pasquali, Julieta, Fuentes, Nora A, Esperatti, Mariano, Speroni, Gerardo A, Nannini, Esteban C, Matteaccio, Alejandra, Michelangelo, Hernán G, Follmann, Dean, Lane, H. Clifford, Belloso, Waldo H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Age Aged Aged, 80 and over Antibodies Antibodies, Neutralizing - blood Blood Component Transfusion Clinical outcomes Clinical trials Coronaviruses COVID-19 COVID-19 - complications COVID-19 - mortality COVID-19 - therapy Disease Disease Progression Double-Blind Method Female Hospitalization Hospitals Humans Hypoxemia Immunization, Passive Immunoglobulin G - blood Influenza Informed consent Kaplan-Meier Estimate Male Middle Aged Mortality Original Patients Placebos Plasma Pneumonia Pneumonia, Viral - etiology Pneumonia, Viral - mortality Pneumonia, Viral - therapy Respiratory diseases SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Statistical analysis
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Zusammenfassung:	Hospitalized adults with severe Covid-19 pneumonia were randomly assigned in a 2:1 ratio to receive convalescent plasma or placebo. At 30 days, no significant difference in clinical status was noted between the two groups. Overall mortality was 11.43% with placebo and 10.96% with convalescent plasma, a difference that was not significant.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2031304