MBCL-09. ISOLATED M1 METASTASES IN PEDIATRIC MEDULLOBLASTOMA: IS POSTOPERATIVE RADIOTHERAPY FOLLOWED BY MAINTENANCE CHEMOTHERAPY SUPERIOR TO POSTOPERATIVE SANDWICH-CHEMOTHERAPY AND RADIOTHERAPY?

Abstract BACKGROUND Impact of isolated spread into the cerebrospinal fluid (CSF) is still not investigated comprehensively for childhood medulloblastoma and the best therapeutic strategy is currently unclear. MATERIAL AND METHODS Sixty-six patients with isolated M1-MB registered to the HIT-MED-datab...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2020-12, Vol.22 (Supplement_3), p.iii389-iii389
Hauptverfasser:	Obrecht, Denise, Mynarek, Martin, Hagel, Christian, Kwiecien, Robert, Spohn, Michael, Bockmayr, Michael L, Bison, Brigitte, Warmuth-Metz, Monika, Pfister, Stefan M, Jones, David T W, Sturm, Dominik, von Deimling, Andreas, Sahm, Felix, von Hoff, Katja, Juhnke, B - Ole, Benesch, Martin, Gerber, Nicolas U, von Bueren, André O, Friedrich, Carsten, Kortmann, Rolf-Dieter, Schwarz, Rudolf, Pietsch, Torsten, Rutkowski, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Medulloblastoma (Clinical)
Online-Zugang:	Volltext
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Zusammenfassung:	Abstract BACKGROUND Impact of isolated spread into the cerebrospinal fluid (CSF) is still not investigated comprehensively for childhood medulloblastoma and the best therapeutic strategy is currently unclear. MATERIAL AND METHODS Sixty-six patients with isolated M1-MB registered to the HIT-MED-database from 2000–2018 were identified. CSF and MRI were centrally reviewed for all patients. Patients were stratified by age and either treated with upfront craniospinal irradiation (CSI) followed by maintenance chemotherapy (CT) or with postoperative CT and delayed CSI. RESULTS Forty-nine patients were non-infants ≥4 years and seventeen were infants
ISSN:	1522-8517 1523-5866
DOI:	10.1093/neuonc/noaa222.485