Single nucleotide vitamin D receptor polymorphisms (FokI, BsmI, ApaI, and TaqI) in the pathogenesis of prematurity complications

The vitamin D receptor (VDR), coded by the VDR gene, plays a pivotal role in executing cellular functions when bound by the active form of vitamin D. Gene polymorphisms in this receptor have been increasingly associated with a heightened state of vulnerability to certain diseases. However, limited d...

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Veröffentlicht in:	Scientific reports 2020-12, Vol.10 (1), p.21098-21098, Article 21098
Hauptverfasser:	Kosik, Katarzyna, Szpecht, Dawid, Al-Saad, Salwan R., Karbowski, Lukasz M., Kurzawińska, Grażyna, Szymankiewicz, Marta, Drews, Krzysztof, Wolski, Hubert, Seremak-Mrozikiewicz, Agnieszka
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4017 692/420 692/499 692/699 Alleles Baby foods Dysplasia Enterocolitis Female Gastrointestinal diseases Gene Frequency Gene polymorphism Genetic Predisposition to Disease Gestation Hemorrhage Humanities and Social Sciences Humans Infant, Newborn Infants Male multidisciplinary Necrosis Necrotizing enterocolitis Neonates Newborn babies Polymorphism, Single Nucleotide - genetics Premature Birth - genetics Receptors, Calcitriol - genetics Respiratory distress syndrome Retinopathy Science Science (multidisciplinary) Vitamin D Vitamin D receptors
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Zusammenfassung:	The vitamin D receptor (VDR), coded by the VDR gene, plays a pivotal role in executing cellular functions when bound by the active form of vitamin D. Gene polymorphisms in this receptor have been increasingly associated with a heightened state of vulnerability to certain diseases. However, limited data is available concerning the role of VDR gene polymorphisms in preterm infant complications. In 114 premature infants (
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-78125-4