Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men

Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men

Background Prostate cancer (PC) risk increases with African ancestry and a history of sexually transmitted infections (STIs). Also, single‐nucleotide polymorphisms (SNPs) in toll‐like receptor (TLR) genes influence PC risk. This pilot study explores interactions between STIs and TLR‐related SNPs in...

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Veröffentlicht in:The Prostate 2020-11, Vol.80 (15), p.1365-1372
Hauptverfasser: Dubey, Bhawna, Jackson, Maria, Zeigler‐Johnson, Charnita, Devarajan, Karthik, Flores‐Obando, Rafael E, McFarlane‐Anderson, Norma, Tulloch‐Reid, Marshall, Aiken, William, Kimbro, Kevin, Reed, Dominique, Kidd, LaCreis R., Gibbs, Denise, Kumar, Sudhir, Ragin, Camille
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
black
Case-Control Studies
Genetic Predisposition to Disease
Genotype
Humans
Hypothesis testing
Interferon regulatory factor 3
Jamaica
Male
Middle Aged
Pilot Projects
Polymorphism, Single Nucleotide
Prostate cancer
Prostatic Neoplasms - etiology
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Risk Assessment
Risk Factors
Sexually transmitted diseases
Sexually Transmitted Diseases - complications
sexually transmitted infections
single nucleotide polymorphisms
Single-nucleotide polymorphism
STD
StepPLR
Toll-like receptors
Toll-Like Receptors - genetics
toll‐like receptor (TLR)
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Zusammenfassung:Background Prostate cancer (PC) risk increases with African ancestry and a history of sexually transmitted infections (STIs). Also, single‐nucleotide polymorphisms (SNPs) in toll‐like receptor (TLR) genes influence PC risk. This pilot study explores interactions between STIs and TLR‐related SNPs in relation to PC risk among Jamaican men. Methods This case‐control study evaluates two TLR related SNPs in 356 Jamaican men (194 controls and 162 cases) with or without history of STIs using stepwise penalized logistic regression in multivariable analyses. Results Age (odds ratio [OR] = 1.08; 95% confidence interval [CI]: 1.04–1>.12; p 
ISSN:0270-4137
1097-0045
DOI:10.1002/pros.24067