Chloroquine Sensitizes GNAQ/11 -mutated Melanoma to MEK1/2 Inhibition

Mutational activation of or ( ), detected in >90% of uveal melanomas, leads to constitutive activation of oncogenic pathways, including MAPK and YAP. To date, chemo- or pathway-targeted therapies, either alone or in combination, have proven ineffective in the treatment of patients with metastatic...

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Veröffentlicht in:	Clinical cancer research 2020-12, Vol.26 (23), p.6374-6386
Hauptverfasser:	Truong, Amanda, Yoo, Jae Hyuk, Scherzer, Michael T, Sanchez, John Michael S, Dale, Kali J, Kinsey, Conan G, Richards, Jackson R, Shin, Donghan, Ghazi, Phaedra C, Onken, Michael D, Blumer, Kendall J, Odelberg, Shannon J, McMahon, Martin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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