Limb Development: Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture (Adv. Sci. 23/2020)

Limb Development: Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture (Adv. Sci. 23/2020)

In article number 2000938, Zi Yin, Junxin Lin, and co‐workers identify a novel musculoskeletal stem cell population by single‐cell transcriptional profiling with lineage tracing data during limb development. The differentiation potential and trajectory of musculoskeletal stem cells showed they could...

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Veröffentlicht in:Advanced science 2020-12, Vol.7 (23), p.n/a
Hauptverfasser: Yin, Zi, Lin, Junxin, Yan, Ruojin, Liu, Richun, Liu, Mengfei, Zhou, Bo, Zhou, Wenyan, An, Chengrui, Chen, Yangwu, Hu, Yejun, Fan, Chunmei, Zhao, Kun, Wu, Bingbing, Zou, Xiaohui, Zhang, Jin, El‐Hashash, Ahmed H., Chen, Xiao, Ouyang, Hongwei
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Sprache:eng
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Zusammenfassung:In article number 2000938, Zi Yin, Junxin Lin, and co‐workers identify a novel musculoskeletal stem cell population by single‐cell transcriptional profiling with lineage tracing data during limb development. The differentiation potential and trajectory of musculoskeletal stem cells showed they could contribute to soft and hard connective tissues, as well as muscular tissue. These results suggest an indispensable role of limb Scx+ musculoskeletal stem cell population in musculoskeletal system morphogenesis.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202070129