Sesquiterpenoid Tropolone Glycosides from Liriosma ovata

Two new sesquiterpenoid tropolone glycosides, liriosmasides A (1) and B (2), along with two known compounds, secoxyloganin and oplopanpheside C, were isolated from a methanol extract of the roots of Liriosma ovata. The structures of 1 and 2 were elucidated by spectroscopic methods including 1D and 2...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2015-02, Vol.78 (2), p.315-319
Hauptverfasser:	Ma, Jun, Pawar, Rahul S, Grundel, Erich, Mazzola, Eugene P, Ridge, Clark D, Masaoka, Takashi, Le Grice, Stuart F. J, Wilson, Jennifer, Beutler, John A, Krynitsky, Alexander J
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid - methods Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Olacaceae - chemistry Peru Plant Roots - chemistry Ribonuclease H - antagonists & inhibitors Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Tropolone - analogs & derivatives Tropolone - chemistry Tropolone - isolation & purification Tropolone - pharmacology
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Beschreibung
Zusammenfassung:	Two new sesquiterpenoid tropolone glycosides, liriosmasides A (1) and B (2), along with two known compounds, secoxyloganin and oplopanpheside C, were isolated from a methanol extract of the roots of Liriosma ovata. The structures of 1 and 2 were elucidated by spectroscopic methods including 1D and 2D NMR and by high-resolution mass spectrometry involving an ultra-high-performance liquid chromatography–quadrupole-orbital ion trap mass spectrometric (UHPLC–Q-Orbitrap MS) method. Compound 1 showed weak inhibitory activity against HIV RNase H.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np5006696