Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes
Highlights • miR-373 identified as a target of epigenetic aberration in NSCLC. • miR-373 acts as a tumor suppressor. • miR-33 is a negative regulator of the EMT in lung cancer. • miR-373 regulates EMT phenotype through IRAK2 and LAMP1.
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| Veröffentlicht in: | Cancer letters 2014-10, Vol.353 (2), p.232-241 |
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| container_issue | 2 |
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| container_title | Cancer letters |
| container_volume | 353 |
| creator | Seol, Hyang Sook Akiyama, Yoshimitsu Shimada, Shu Lee, Hee Jin Kim, Tae Im Chun, Sung Min Singh, Shree Ram Jang, Se Jin |
| description | Highlights • miR-373 identified as a target of epigenetic aberration in NSCLC. • miR-373 acts as a tumor suppressor. • miR-33 is a negative regulator of the EMT in lung cancer. • miR-373 regulates EMT phenotype through IRAK2 and LAMP1. |
| doi_str_mv | 10.1016/j.canlet.2014.07.019 |
| format | Article |
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metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Confidence intervals</subject><subject>Deoxyribonucleic acid</subject><subject>Disease-Free Survival</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Histone deacetylase</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Interleukin-1 Receptor-Associated Kinases - metabolism</subject><subject>IRAK2</subject><subject>Kaplan-Meier Estimate</subject><subject>Kinases</subject><subject>LAMP1</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lysosomal Membrane Proteins - metabolism</subject><subject>Male</subject><subject>Metastasis</subject><subject>microRNA-373</subject><subject>MicroRNAs</subject><subject>MicroRNAs - metabolism</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Non-small cell lung cancer</subject><subject>Proportional Hazards Models</subject><subject>Protein Processing, Post-Translational</subject><subject>Survival analysis</subject><subject>Tumor suppressor</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1DAUhSMEotPCP0DIEusEPxLb2SCNqgIVw0MF1pbHuZl4cOypnVTMvj8cj6a0wIaNLdnnnnt8PxfFC4Irggl_va2M9g6mimJSV1hUmLSPigWRgpailfhxscAM1yWTrDkpTlPaYoybWjRPixPaYM4Ek4vi9mJnN-BhsgYl68Ab6zco9Gi0JoarT8sy69AUEOzsNICz2pUjpKwb9qN2aIraJzvZ4JH1yAdfpnzskIG8uDl75ZQGIpqGGObNgC6vlh8o0r5Dq-XHLwTpn5CeFU967RI8v9vPiu9vL76dvy9Xn99dni9XpeGSTqVutdS0r0Vf8zXXsNaGiNoISUzPasmbjmsjGDGy030rO9r0ou1MT9m6Fowydla8Ofru5vUInQGf4zu1i3bUca-CturvG28HtQk3SggsKGuzwas7gxiuZ0iT2oY5-pxZEU6YJJwxklX1UZUnmFKE_r4DwerATm3VkZ06sFNYqMwul738M9190W9YD_Ehz-jGQlTJ2EwCOhvBTKoL9n8d_jUwznprtPsBe0gPb1GJKqy-Hv7P4fuQGmPGuWS_AKo8wx8</recordid><startdate>20141028</startdate><enddate>20141028</enddate><creator>Seol, Hyang Sook</creator><creator>Akiyama, Yoshimitsu</creator><creator>Shimada, Shu</creator><creator>Lee, Hee Jin</creator><creator>Kim, Tae Im</creator><creator>Chun, Sung Min</creator><creator>Singh, Shree Ram</creator><creator>Jang, Se Jin</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope></search><sort><creationdate>20141028</creationdate><title>Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes</title><author>Seol, Hyang Sook ; Akiyama, Yoshimitsu ; Shimada, Shu ; Lee, Hee Jin ; Kim, Tae Im ; Chun, Sung Min ; Singh, Shree Ram ; Jang, Se Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c682t-a9a8a2f47f46b6aebac174c781cf34865d6ac731c8daf98d25f79dcf23b473233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Confidence intervals</topic><topic>Deoxyribonucleic acid</topic><topic>Disease-Free Survival</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Histone deacetylase</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Interleukin-1 Receptor-Associated Kinases - metabolism</topic><topic>IRAK2</topic><topic>Kaplan-Meier Estimate</topic><topic>Kinases</topic><topic>LAMP1</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - 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| ispartof | Cancer letters, 2014-10, Vol.353 (2), p.232-241 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Cell growth Cell Line, Tumor Confidence intervals Deoxyribonucleic acid Disease-Free Survival DNA DNA methylation Epigenesis, Genetic Epigenetics Epithelial-Mesenchymal Transition Female Gene expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Histone deacetylase Histones - metabolism Humans Interleukin-1 Receptor-Associated Kinases - metabolism IRAK2 Kaplan-Meier Estimate Kinases LAMP1 Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Lysosomal Membrane Proteins - metabolism Male Metastasis microRNA-373 MicroRNAs MicroRNAs - metabolism Mortality Multivariate Analysis Non-small cell lung cancer Proportional Hazards Models Protein Processing, Post-Translational Survival analysis Tumor suppressor |
| title | Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes |
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